NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
BMJ Open. 2021 Mar 17;11(3):e044899. doi: 10.1136/bmjopen-2020-044899.
To describe the frequency of symptoms compatible with SARS-CoV-2 infection in immunocompromised children and young people in the UK during the SARS-CoV-2 pandemic. To describe patient/parent anxiety regarding SARS-CoV-2 infection in this cohort.
A prospective observational cohort study.
46 centres across the UK between 16 March and 4 July 2020. A weekly online questionnaire based on the International Severe Acute Respiratory and emerging Infections Consortium-WHO Case Report Form was used to collect participant reported data on symptoms, test results, National Health Service attendance, hospital admission and impact on daily life.
1490 immunocompromised children, defined as those requiring an annual influenza vaccination due to their underlying condition or medication.
Incidence of SARS-CoV-2-like symptoms and patient/parent anxiety score.
Over 16 weeks during the first wave of the pandemic, no SARS-CoV-2 infection was diagnosed in this large immunocompromised paediatric cohort (median age 11 years, 54.4% female). 110 symptomatic participants underwent a test for SARS-CoV-2; all were negative. 922 (67.4%) participants reported at least one symptom consistent with suspected SARS-CoV-2 infection over the study period. 476 (34.8%) reported three or more symptoms. The most frequently reported symptoms included joint pain, fatigue, headache, nausea and muscle pain. SARS-CoV-2 testing during this period was performed on admitted patients only. 137 participants had their medication suspended or changed during the study period due to assumed COVID-19 disease risk. 62% reported high levels of anxiety (scores of 7-10 out of 10) at the start of the study, with anxiety levels remaining high throughout the study period.
Although symptoms related to SARS-CoV-2 infection in children were common, there were no positive tests in this large immunocompromised cohort. Symptom-based screening to facilitate early detection of SARS-CoV-2 infection may not be helpful in these individuals. Patient/parent anxiety about SARS-CoV-2 infection was high.
NCT04382508.
描述英国 SARS-CoV-2 大流行期间免疫功能低下的儿童和青少年中符合 SARS-CoV-2 感染症状的频率。描述该队列中患者/家长对 SARS-CoV-2 感染的焦虑。
前瞻性观察队列研究。
2020 年 3 月 16 日至 7 月 4 日期间，英国 46 个中心。每周使用基于国际严重急性呼吸和新兴感染联合会-世界卫生组织病例报告表的在线问卷收集参与者报告的症状、检测结果、国民保健服务就诊、住院和日常生活影响的数据。
1490 名免疫功能低下的儿童，定义为因基础疾病或药物而需要每年接种流感疫苗的儿童。
SARS-CoV-2 样症状的发生率和患者/家长焦虑评分。
在大流行的第一波期间的 16 周内，未在该大型免疫功能低下儿科队列中诊断出 SARS-CoV-2 感染（中位年龄 11 岁，54.4%为女性）。110 名有症状的参与者接受了 SARS-CoV-2 检测；均为阴性。922 名（67.4%）参与者在研究期间报告了至少一种疑似 SARS-CoV-2 感染的症状。476 名（34.8%）报告了三种或更多症状。最常报告的症状包括关节痛、疲劳、头痛、恶心和肌肉疼痛。在此期间，仅对住院患者进行了 SARS-CoV-2 检测。由于担心 COVID-19 疾病风险，137 名参与者在研究期间暂停或改变了药物治疗。62%的人在研究开始时报告了高水平的焦虑（10 分制中得分为 7-10 分），整个研究期间焦虑水平一直很高。
尽管儿童 SARS-CoV-2 感染相关症状很常见，但在这个大型免疫功能低下队列中没有阳性检测结果。基于症状的筛查可能无助于这些人群中 SARS-CoV-2 感染的早期发现。患者/家长对 SARS-CoV-2 感染的焦虑很高。
NCT04382508。
