Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Front Endocrinol (Lausanne). 2022 Mar 4;13:794947. doi: 10.3389/fendo.2022.794947. eCollection 2022.
To assess the association between vitamin D status and all-cause mortality among type 2 diabetes patients.
We prospectively followed 1,291 participants with type 2 diabetes aged 20-80 years during 2013-2018. Cox proportional hazard regression models were used to estimate the association between different vitamin D status and all-cause mortality risk among hospitalized patients with type 2 diabetes.
During a median follow-up of 4.15 years (5,365 person-years in total), 61 cases of death were identified. Multivariable-adjusted hazard ratios (HRs) for all-cause mortality across the quartiles of baseline circulating 25-hydroxy vitamin D (25-OH vitamin D) were 2.70 [95% confidence interval (CI) 1.12-6.54], 1.00, 1.39 (95% CI 0.53-3.65), 2.31 (95% CI 0.96-5.54), respectively. Multivariable-adjusted HRs for all-cause mortality by different groups of baseline 25-OH vitamin D concentrations (<25, 25-49, 50-100, and ≥100 nmol/L) were 1.31 (95% CI 0.58-2.96), 0.94 (95% CI 0.47-1.87), 1.00, and 3.58 (95% CI 1.43-8.98), respectively.
Very low or high concentrations of vitamin D may be associated with a higher risk of all-cause mortality among patients with type 2 diabetes.
评估 2 型糖尿病患者维生素 D 状态与全因死亡率之间的关系。
我们前瞻性随访了 1291 名年龄在 20-80 岁的 2 型糖尿病患者，随访时间为 2013 年至 2018 年。使用 Cox 比例风险回归模型来估计不同维生素 D 状态与住院 2 型糖尿病患者全因死亡率风险之间的关系。
在中位随访 4.15 年（总随访时间为 5365 人年）期间，有 61 例死亡。按基线循环 25-羟维生素 D（25-OH 维生素 D）四分位数划分的全因死亡率的多变量调整后危险比（HRs）分别为 2.70 [95%置信区间（CI）1.12-6.54]、1.00、1.39（95%CI 0.53-3.65）、2.31（95%CI 0.96-5.54）。按基线 25-OH 维生素 D 浓度（<25、25-49、50-100 和≥100 nmol/L）不同分组的全因死亡率的多变量调整后 HRs 分别为 1.31（95%CI 0.58-2.96）、0.94（95%CI 0.47-1.87）、1.00 和 3.58（95%CI 1.43-8.98）。
维生素 D 浓度非常低或非常高可能与 2 型糖尿病患者全因死亡率升高相关。
