National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
College of Life Sciences, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, China.
Bioconjug Chem. 2022 Apr 20;33(4):726-735. doi: 10.1021/acs.bioconjchem.2c00100. Epub 2022 Mar 21.
The combination of photothermal therapy and chemical drug therapy shows good prospects in cancer treatment, but there are also some limitations such as low permeability of therapeutic agents and uneven photothermal therapy. Here, we synthesized a walnut-shaped polydopamine (PDA) nanomotor driven by near infrared (NIR) light. The nanomotor was modified by methoxy polyethylene glycol amine (mPEG-NH) for improving water solubility. PDA-PEG loaded adriamycin through π-π accumulation and hydrogen bonding. The experimental results showed that the PDA nanomotors had good biocompatibility and photothermal effect. Further, the NIR light irradiation and tumor cell microenvironment are conducive to drug release. In addition, under the irradiation of an NIR laser, the asymmetry of walnut-shaped nanoparticles makes the particles obtain the ability of autonomous movement, which can improve the permeability of particles in 3D tumor balls, which can provide support for drug penetration and heat dispersion. This strategy offers potential innovative materials for photothermal/chemotherapy synergistic therapy of tumors.
光热治疗与化学药物治疗相结合在癌症治疗中具有广阔的前景，但也存在一些局限性，如治疗剂的通透性低和光热治疗不均匀。在这里，我们合成了一种由近红外（NIR）光驱动的胡桃形聚多巴胺（PDA）纳米马达。该纳米马达通过甲氧基聚乙二醇胺（mPEG-NH）进行修饰以提高水溶性。PDA-PEG 通过 π-π 堆积和氢键装载阿霉素。实验结果表明，PDA 纳米马达具有良好的生物相容性和光热效应。此外，近红外光照射和肿瘤细胞微环境有利于药物释放。此外，在近红外激光照射下，胡桃形纳米颗粒的不对称性使颗粒获得了自主运动的能力，从而提高了 3D 肿瘤球中颗粒的通透性，为药物渗透和热量分散提供了支持。该策略为肿瘤的光热/化学协同治疗提供了潜在的创新材料。
