Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong 518055, China.
Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Beijing 100044, China.
ACS Nano. 2022 Apr 26;16(4):5647-5659. doi: 10.1021/acsnano.1c10618. Epub 2022 Mar 21.
Challenges remain in precisely diagnosing the progress of liver fibrosis in a noninvasive way. We here synthesized small (4 nm) heterogeneous iron oxide/dysprosium oxide nanoparticles (IO-DyO NPs) as a contrast agent (CA) for magnetic resonance imaging (MRI) to precisely diagnose liver fibrosis at both 7.0 and 9.4 T field strength. Our IO-DyO NPs can target the liver and show an increased relaxivity along with an increase of magnetic field strength. At a ultrahigh magnetic field, IO-DyO NPs can significantly improve spatial/temporal image resolution and signal-to-noise ratio of the liver and precisely distinguish the early and moderate liver fibrosis stages. Our IO-DyO NP-based MRI diagnosis can exactly match biopsy (a gold standard for liver fibrosis diagnosis in the clinic) but avoid the invasiveness of biopsy. Moreover, our IO-DyO NPs show satisfactory biosafety and . This work illustrates an advanced CA used in ultrahigh-field MRI (UHFMRI) for the precise diagnosis of liver fibrosis a noninvasive means.
用非侵入性方法精确诊断肝纤维化进展仍然存在挑战。我们在这里合成了小（4nm）异质氧化铁/钆氧化物纳米颗粒（IO-DyO NPs）作为磁共振成像（MRI）的对比剂（CA），以在 7.0 和 9.4T 场强下精确诊断肝纤维化。我们的 IO-DyO NPs 可以靶向肝脏，并表现出随着磁场强度增加而增加的弛豫率。在超高磁场下，IO-DyO NPs 可以显著提高肝脏的空间/时间图像分辨率和信噪比，并精确区分早期和中度肝纤维化阶段。我们基于 IO-DyO NP 的 MRI 诊断可以与活检（临床肝纤维化诊断的金标准）完全匹配，但避免了活检的侵入性。此外，我们的 IO-DyO NPs 表现出令人满意的生物安全性。这项工作说明了在超高场 MRI（UHFMRI）中使用先进的 CA 来精确诊断肝纤维化——一种非侵入性手段。
