Liu Yuting, Lin Ziqi, Wang Yuting, Chen Liuhui, Wang Yuequan, Luo Cong
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China.
Theranostics. 2024 Apr 8;14(6):2490-2525. doi: 10.7150/thno.91394. eCollection 2024.
Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases. Accurate detection and timely therapeutic intervention on inflammatory dysregulation are crucial for the effective therapy of inflammation-associated diseases. However, the clinical outcomes of inflammation-involved disorders are still unsatisfactory. Therefore, there is an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations with traditional therapeutics. Biomedical nanotechnology is one of the promising fields that can potentially transform the diagnosis and treatment of inflammation. In this review, we outline recent advances in biomedical nanotechnology for the diagnosis and treatment of inflammation, with special attention paid to nanosensors and nanoprobes for precise diagnosis of inflammation-related diseases, emerging anti-inflammatory nanotherapeutics, as well as nanotheranostics and combined anti-inflammatory applications. Moreover, the prospects and challenges for clinical translation of nanoprobes and anti-inflammatory nanomedicines are highlighted.
炎症调节异常与许多危及生命的疾病的发生和发展密切相关。对炎症调节异常进行准确检测并及时进行治疗干预对于有效治疗炎症相关疾病至关重要。然而，炎症相关疾病的临床疗效仍不尽人意。因此，迫切需要通过将新兴技术创新与传统疗法相结合来开发创新的抗炎策略。生物医学纳米技术是一个有潜力改变炎症诊断和治疗的领域之一。在这篇综述中，我们概述了生物医学纳米技术在炎症诊断和治疗方面的最新进展，特别关注用于精确诊断炎症相关疾病的纳米传感器和纳米探针、新兴的抗炎纳米疗法，以及纳米诊疗和联合抗炎应用。此外，还强调了纳米探针和抗炎纳米药物临床转化的前景和挑战。
