Head and Neck Pathology Consultations, 22543 Ventura Boulevard, Ste 220 PMB1034, Woodland Hills, CA, 91364, USA.
University of Texas Southwestern Medical Center, Clements University Hospital, UH04.250, 6201 Harry Hines Blvd., Dallas, TX, 75390, USA.
Head Neck Pathol. 2022 Mar;16(1):1-18. doi: 10.1007/s12105-021-01406-5. Epub 2022 Mar 21.
The World Health Organization Classification of Head and Neck Tumours recently published the 5th edition. There are new entities, emerging entities, and significant updates to the taxonomy and characterization of tumor and tumor-like lesions, specifically in this article as it relates to nasal cavity, paranasal sinuses and skull base. Importantly, the number of diagnostic entries has been reduced by creating category-specific chapters for soft tissue, hematolymphoid, melanocytic, neuroectodermal, and metastatic tumors. Bone and salivary gland tumors are also not separately reported in the sinonasal tract, but included in the jaw and salivary gland sections, respectively. Repetition of characteristic entities in each anatomic site was also reduced, instead highlighting only the unique features in each anatomic site. Two new entities (SWI/SNF complex-deficient sinonasal carcinomas and HPV-related multiphenotypic sinonasal carcinoma) will be highlighted in this review, with a discussion of several emerging entities. There is a short description of updated information for all 24 diagnostic entities included in this edition to allow the reader a snapshot of current state of knowledge, but to encourage more investigation and further broaden understanding of these diverse and rare entities.
世界卫生组织（WHO）头颈部肿瘤分类最近发布了第 5 版。在肿瘤和肿瘤样病变的分类和特征方面，出现了新的实体、新兴实体，以及重大更新，特别是在鼻腔、副鼻窦和颅底方面。重要的是，通过为软组织、血液淋巴系统、黑色素细胞、神经外胚层和转移性肿瘤创建特定类别章节，减少了诊断条目的数量。骨肿瘤和唾液腺肿瘤也没有分别在鼻窦道中报告，而是分别归入颌骨和唾液腺部分。每个解剖部位的特征性实体的重复也减少了，而是强调了每个解剖部位的独特特征。本文将重点介绍两种新的实体（SWI/SNF 复合物缺陷型鼻腔鼻窦癌和 HPV 相关多表型鼻腔鼻窦癌），并讨论几种新兴实体。本文简短描述了这一版中包含的所有 24 个诊断实体的更新信息，使读者能够了解当前的知识状况，但鼓励更多的研究，并进一步扩大对这些多样化和罕见实体的理解。
