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头颈部NUT癌：一例报告及文献综述。

NUT carcinoma of the head and neck: A case report and literature review.

作者信息

Zhao Yue, Zhang Jun, Liao Wenjun, Li Jiayu, Zhang Shichuan

机构信息

Department of Radiation Oncology Radiation Oncology Key Laboratory of Sichuan Province Sichuan Clinical Research Center for Cancer Sichuan Cancer Hospital &Institute Sichuan Cancer Center Affiliated Cancer Hospital of University of Electronic Science and Technology of China Chengdu Sichuan China.

Department of Pathology Sichuan Clinical Research Center for Cancer Sichuan Cancer Hospital & Institute Sichuan Cancer Center Affiliated Cancer Hospital of University of Electronic Science and Technology of China Chengdu China.

出版信息

Precis Radiat Oncol. 2024 Sep 1;8(3):138-144. doi: 10.1002/pro6.1237. eCollection 2024 Sep.

DOI:10.1002/pro6.1237
PMID:40336973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11935197/
Abstract

Nuclear protein in testis (NUT) carcinoma is a rare and highly aggressive cancer, characterized by rearrangements involving the gene located on chromosome 15q14. In this report, we present the case of a 52-year-old female diagnosed with primary parotid NUT carcinoma. Despite undergoing surgery, adjuvant chemotherapy, and incomplete regional radiotherapy, the patient succumbed to the disease after an overall survival duration of 7 months. We retrospectively discuss patient clinical and pathological features, as well as therapeutic approaches of NUT carcinoma of the head and neck.

摘要

睾丸核蛋白（NUT）癌是一种罕见且侵袭性很强的癌症，其特征是涉及位于15号染色体q14区域的基因重排。在本报告中，我们介绍了一名52岁女性被诊断为原发性腮腺NUT癌的病例。尽管接受了手术、辅助化疗和不完全的局部放疗，但患者在总生存期7个月后死于该疾病。我们回顾性地讨论了患者的临床和病理特征，以及头颈部NUT癌的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/2666fb467359/PRO6-8-138-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/5876e3b1a88f/PRO6-8-138-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/726ebead1409/PRO6-8-138-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/abcb012c92cb/PRO6-8-138-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/2666fb467359/PRO6-8-138-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/5876e3b1a88f/PRO6-8-138-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/726ebead1409/PRO6-8-138-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/abcb012c92cb/PRO6-8-138-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/11935197/2666fb467359/PRO6-8-138-g001.jpg

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本文引用的文献

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Therapeutic approaches to sinonasal NUT carcinoma: a systematic review.治疗鼻窦 NUT 癌的方法：系统评价。
Eur Arch Otorhinolaryngol. 2024 Jul;281(7):3361-3369. doi: 10.1007/s00405-024-08489-0. Epub 2024 Feb 8.
2
High-Grade Spindle Cell Sarcoma of the Scalp With an MGA::NUTM1 Gene Fusion in a Pediatric Patient.头皮高级别梭形细胞肉瘤伴儿科患者的 MGA::NUTM1 基因融合。
Am J Dermatopathol. 2024 Feb 1;46(2):101-103. doi: 10.1097/DAD.0000000000002605. Epub 2023 Dec 6.
3
EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes.
EZH2 通过沉默关键肿瘤抑制基因与 BRD4-NUT 协同驱动 NUT 癌生长。
Cancer Res. 2023 Dec 1;83(23):3956-3973. doi: 10.1158/0008-5472.CAN-23-1475.
4
Phase Ia dose-escalation trial with the BET protein inhibitor BI 894999 in patients with advanced or metastatic solid tumours.BET 蛋白抑制剂 BI 894999 治疗晚期或转移性实体瘤患者的 Ia 期剂量递增试验。
Eur J Cancer. 2023 Sep;191:112987. doi: 10.1016/j.ejca.2023.112987. Epub 2023 Jul 11.
5
An Unusual Case of a Scrotal Porocarcinoma and Review of the Literature.阴囊汗孔癌1例罕见病例并文献复习
Am J Dermatopathol. 2023 Jan 1;45(1):51-55. doi: 10.1097/DAD.0000000000002327. Epub 2022 Nov 2.
6
Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review.原发性肺 NUT 癌的诊断、治疗与预后：文献综述。
Curr Oncol. 2022 Sep 22;29(10):6807-6815. doi: 10.3390/curroncol29100536.
7
NUT Carcinoma-An Underdiagnosed Malignancy.NUT癌——一种诊断不足的恶性肿瘤。
Front Oncol. 2022 Jul 26;12:914031. doi: 10.3389/fonc.2022.914031. eCollection 2022.
8
The contemporary management of cancers of the sinonasal tract in adults.成人鼻窦肿瘤的当代治疗方法。
CA Cancer J Clin. 2023 Jan;73(1):72-112. doi: 10.3322/caac.21752. Epub 2022 Aug 2.
9
Report of the First International Symposium on NUT Carcinoma.NUT 癌第一届国际研讨会报告。
Clin Cancer Res. 2022 Jun 13;28(12):2493-2505. doi: 10.1158/1078-0432.CCR-22-0591.
10
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Nasal Cavity, Paranasal Sinuses and Skull Base.世界卫生组织头颈部肿瘤分类第五版更新：鼻腔、副鼻窦和颅底。
Head Neck Pathol. 2022 Mar;16(1):1-18. doi: 10.1007/s12105-021-01406-5. Epub 2022 Mar 21.