Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.
Expert Opin Pharmacother. 2022 Apr;23(6):703-711. doi: 10.1080/14656566.2022.2049238. Epub 2022 Mar 22.
Glucocorticoids are steroid hormones broadly used for the treatment of several inflammatory and autoimmune diseases among other numerous indications, including rheumatoid arthritis.
For the purposes of this article, the authors have performed an extensive review of the literature to present the latest studies on glucocorticoid use in rheumatoid arthritis. They also provide the reader with their expert perspectives on future developments.
The authors do not anticipate that glucocorticoids with be replaced in the near future by newer drugs. As such, rheumatologists should be fully aware of the possible side-effects and educate appropriately their patients to recognize and report them. Newer formulations, such as the liposomal/nanoparticle-based treatments, will result in less pronounced adverse effects, but the input of clinical experience along with the current recommendations for the glucocorticoid use will benefit both clinicians and patients with rheumatoid arthritis.
糖皮质激素被广泛用于治疗多种炎症性和自身免疫性疾病，以及许多其他适应症，包括类风湿关节炎。
为了撰写本文，作者对文献进行了广泛的回顾，以呈现最新的关于糖皮质激素在类风湿关节炎中的应用研究。他们还为读者提供了对未来发展的专家意见。
作者预计在不久的将来，不会有更新的药物替代糖皮质激素。因此，风湿病医生应该充分了解可能的副作用，并对患者进行适当的教育，以识别和报告这些副作用。新的制剂，如基于脂质体/纳米颗粒的治疗方法，将导致不太明显的不良反应，但临床经验的投入以及目前关于糖皮质激素使用的建议将使类风湿关节炎的临床医生和患者受益。
