Kirwan John, Power Lynsey
University of Bristol Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK.
Curr Opin Rheumatol. 2007 May;19(3):233-7. doi: 10.1097/BOR.0b013e3280d6471a.
To summarize the mechanism of action of glucocorticoids, the direction that current research is taking and what this might mean for clinicians.
New cellular actions of glucocorticoids have been identified, and offer new drug targets. There is increasing competition to find a glucocorticoid formulation or analogue that enhances therapeutic effects while reducing adverse effects. Clinically, there is increasing evidence for the disease-modifying effects of glucocorticoids, which makes these developments topical and relevant. Better understanding of the pathology of rheumatoid arthritis and the circadian variation in symptoms that is a hallmark of the disease may also affect the way that we use these drugs.
Glucocorticoids are about to enter a renaissance based on better understanding of how they work and novel approaches to new therapeutic targets.
总结糖皮质激素的作用机制、当前研究方向以及这对临床医生可能意味着什么。
已确定糖皮质激素的新细胞作用，并提供了新的药物靶点。寻找能增强治疗效果同时减少不良反应的糖皮质激素制剂或类似物的竞争日益激烈。临床上，越来越多的证据表明糖皮质激素具有改善病情的作用，这使得这些进展具有时效性和相关性。对类风湿关节炎病理学以及该疾病标志性症状昼夜变化的更好理解，也可能影响我们使用这些药物的方式。
基于对糖皮质激素作用方式的更好理解以及针对新治疗靶点的新方法，糖皮质激素即将迎来复兴。
