Department of Pharmacy, Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, P.O. Box 14, Birzeit, West Bank, Palestine.
Department of Internal Medicine, Al-Quds School of Medicine, P.O. Box 17233, East Jerusalem, Palestine.
BMC Cancer. 2022 Mar 21;22(1):295. doi: 10.1186/s12885-022-09420-8.
Breast cancer (BC) is the most common cancer among women. Studies have shown that cancer patients can develop depression impacting their quality of life, treatment outcomes, and survival rates. This study aimed to determine the risk factors, severity and prevalence of depression among females diagnosed with BC in multiple hospitals across Palestine.
A cross-sectional study was conducted at different cancer treatment centers in Palestine using a previously developed questionnaire consisting of 23 questions to assess the severity of major depressive disorder among females diagnosed with breast cancer. The Patient Health Questionnaire-9 (PHQ-9) was included in the questionnaire.
Out of 223 respondents, 79 (35.4%) have developed moderate to severe depression. Chi-square results revealed that the risk of developing moderate to severe depression was higher among females who suffer from side-effects related to BC treatment (P < 0.011), females who knew the BC stage at the diagnosis step (P < 0.031), and negative implications on BC patients in Palestine (P < 0.009).
Breast cancer patients have an increased risk of developing major depressive disorder. Patient assessment and treatment for depression at the time of BC diagnosis, during the treatment journey, and monitoring after treatment completion is essential for patient quality of life and BC treatment outcomes.
乳腺癌（BC）是女性中最常见的癌症。研究表明，癌症患者可能会患上抑郁症，从而影响他们的生活质量、治疗效果和生存率。本研究旨在确定巴勒斯坦多家医院诊断为 BC 的女性中抑郁症的风险因素、严重程度和患病率。
在巴勒斯坦不同的癌症治疗中心进行了一项横断面研究，使用先前开发的问卷，该问卷由 23 个问题组成，用于评估诊断为乳腺癌的女性中重度抑郁症的严重程度。问卷中包括患者健康问卷-9（PHQ-9）。
在 223 名受访者中，有 79 名（35.4%）出现了中度至重度抑郁。卡方检验结果表明，与 BC 治疗相关的副作用（P < 0.011）、在诊断阶段就知道 BC 分期（P < 0.031）以及 BC 对巴勒斯坦患者的负面影响（P < 0.009）的女性发生中度至重度抑郁的风险更高。
乳腺癌患者发生重度抑郁症的风险增加。在 BC 诊断时、治疗期间以及治疗完成后监测患者的抑郁情况并进行治疗，对患者的生活质量和 BC 治疗效果至关重要。
