Facultad de Psicología, University of Huanuco, Huanuco, Peru; Banco de Tejidos Tumorales, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Instituto Peruano de Neurociencias, Lima, Peru.
Semin Oncol. 2020 Oct;47(5):293-301. doi: 10.1053/j.seminoncol.2020.08.003. Epub 2020 Sep 4.
We sought to review literature on the prevalence of symptoms of depression in women with a diagnosis of breast cancer (BC) and in the Peruvian population determine the prevalence of symptoms of depression and to describe the association with sociodemographic characteristics. Descriptive cross-sectional analytical study of 254 patients from the National Cancer Institute of Peru (Instituto Nacional de Enfermedades Neoplásicas) with a diagnosis of clinical stage I or II BC. The patients included women aged between 26 and 67 years old. Symptoms of depression were monitored by the Beck Depression Inventory-II. Moreover, clinical features and patient sociodemographic characteristics were analyzed and their association with depression was assessed by logistic regression. The average age of the patients was 47.8 ± 9.2 years; 5.4% of the patients were postmenopausal at the time of the questionnaire. About 55% of women were from Lima, 58.3% had completed secondary education (11 ± 3.2 years), 45.7% were not working, and 46.5% were single. The prevalence of depression was 25.6% at the time of BC diagnosis. Of those patients with symptoms of depression, 16.9% showed symptoms of mild depression, 6.3% moderate, and 2.4% severe. A multivariable logistic regression model showed that in Peruvian women with a diagnosis of BC being married or employed significantly decreased the odds of presenting depressive symptoms (P = 0.029 and 0.017, respectively). Our main limitation was the lack of evaluation of depressive symptoms before the diagnosis, during or at the end of treatment. Another limitation was that the Beck Depression Inventory-II test could only identify depressive symptoms, but not depression as a disease. We have reviewed relevant literature on depression in women with a diagnosis of BC. The data presented suggests an association between both employment and marital status with depressive symptoms among Peruvian women with a diagnosis of BC. Pre-emptive support for women at risk could influence resilience and/or motivation for compliance with antineoplastic treatments.
我们旨在回顾文献中关于患有乳腺癌（BC）的女性和秘鲁人群中抑郁症状的患病率，并确定抑郁症状的患病率，并描述其与社会人口统计学特征的关联。这是一项针对秘鲁国立癌症研究所（Instituto Nacional de Enfermedades Neoplásicas） 254 名临床 I 或 II 期 BC 女性患者的描述性横断面分析研究。患者年龄在 26 至 67 岁之间。通过贝克抑郁量表 II 监测抑郁症状。此外，分析了患者的临床特征和社会人口统计学特征，并通过逻辑回归评估了它们与抑郁的相关性。患者的平均年龄为 47.8 ± 9.2 岁；在问卷调查时，5.4%的患者处于绝经后状态。约 55%的女性来自利马，58.3%完成了中等教育（11 ± 3.2 年），45.7%未工作，46.5%为单身。在诊断为 BC 时，抑郁的患病率为 25.6%。在有抑郁症状的患者中，16.9%为轻度抑郁，6.3%为中度抑郁，2.4%为重度抑郁。多变量逻辑回归模型显示，在被诊断为 BC 的秘鲁女性中，已婚或就业显著降低了出现抑郁症状的几率（分别为 P=0.029 和 0.017）。我们的主要局限性在于缺乏对诊断前、治疗期间或结束时抑郁症状的评估。另一个限制是贝克抑郁量表 II 测试只能识别抑郁症状，而不能识别疾病性抑郁。我们已经回顾了关于诊断为 BC 的女性的抑郁相关文献。所提出的数据表明，在被诊断为 BC 的秘鲁女性中，就业和婚姻状况与抑郁症状之间存在关联。对有风险的女性进行预防性支持可能会影响她们对肿瘤治疗的适应能力和/或动力。
