Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.
Department of Surgery, Arash Women's Hospital, Tehran University of Medical Sciences, Shahid Baghdarnia (North Rashid) Street, Ressalat Street, 1653915911, Tehran, Iran.
BMC Womens Health. 2022 Mar 21;22(1):81. doi: 10.1186/s12905-022-01663-8.
Endometriosis is a common benign but painful gynecologic condition. Studies suggest that the risk of some types of malignancies such as breast cancer is higher in women with endometriosis. Mammographic breast density (MBD) is known as an important predictor for breast cancer. The present study aimed to investigate the potential relationship between endometriosis and MBD.
This cross-sectional study was conducted on 370 women over 40 years of age. Laparoscopic surgery was carried out for the diagnosis of endometriosis. MBD was classified into four categories according to the ACR BI-RADS classification. Statistical analysis was performed using SPSS software to evaluate the potential association between variables.
The mean age of all participants was 47.2 ± 6.4 years, and most participants (76.8%) were premenopausal. Multivariate analysis of the potential predictors of MBD, including age, body mass index, oral contraceptive consumption, progesterone consumption, family history of breast cancer and endometriosis showed that age (P value = 0.002), history of progesterone consumption (P value = 0.004) and endometriosis (P value = 0.006) were independent factors for MBD.
This study indicated that endometriosis had an inverse association with MBD. Age and history of progesterone use were also independent influential factors for MBD. This finding shows that the positive association between breast cancer and endometriosis is not mediated through MBD.
子宫内膜异位症是一种常见的良性但疼痛的妇科疾病。研究表明，子宫内膜异位症患者患某些类型恶性肿瘤（如乳腺癌）的风险较高。乳腺 X 线摄影乳房密度（MBD）是乳腺癌的一个重要预测因素。本研究旨在探讨子宫内膜异位症与 MBD 之间的潜在关系。
本横断面研究共纳入 370 名年龄在 40 岁以上的女性。腹腔镜手术用于诊断子宫内膜异位症。MBD 根据 ACR BI-RADS 分类分为四类。使用 SPSS 软件进行统计分析，以评估变量之间的潜在关联。
所有参与者的平均年龄为 47.2±6.4 岁，大多数参与者（76.8%）处于绝经前。对 MBD 的潜在预测因素（包括年龄、体重指数、口服避孕药使用、孕激素使用、乳腺癌家族史和子宫内膜异位症）进行多变量分析显示，年龄（P 值=0.002）、孕激素使用史（P 值=0.004）和子宫内膜异位症（P 值=0.006）是 MBD 的独立因素。
本研究表明，子宫内膜异位症与 MBD 呈负相关。年龄和孕激素使用史也是 MBD 的独立影响因素。这一发现表明，乳腺癌与子宫内膜异位症之间的正相关关系不是通过 MBD 介导的。
