Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany.
Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany.
J Med Case Rep. 2022 Mar 22;16(1):119. doi: 10.1186/s13256-022-03340-8.
During the severe acute respiratory syndrome coronavirus 2 pandemic, several patient groups are at particular risk. Mortality is higher among cancer patients and may be increased further by thromboembolic events, which are more common in coronavirus 2019 patients according to recent publications. We discuss the association of gynecologic malignancies, Severe acute respiratory syndrome coronavirus 2, and thromboembolism by reporting a case study and summarizing available literature.
A 71-year-old Caucasian patient with ovarian cancer receiving first-line chemotherapy was diagnosed with deep vein thrombosis and pulmonary embolism. Routine screening revealed infection with severe acute respiratory syndrome coronavirus 2 in absence of specific symptoms. After uneventful recovery, oncologic treatment could be continued a few weeks later.
We performed a systematic review of the literature on PubMed following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The search included articles ahead of print, published between 1 December 2019 and 1 June 2020. Cross-searches were conducted on all relevant articles.
We identified five articles meeting the defined criteria, including two retrospective studies, a review, a position paper, as well as a letter to the editor.
Cancer patients infected with severe acute respiratory syndrome coronavirus 2 have a relatively poor outcome, which may partially be due to a higher rate of thromboembolic events. Thromboprophylaxis is recommended, and scoring systems are helpful in early detection. In cancer patients with severe acute respiratory syndrome coronavirus 2, individual risk for thromboembolic events should be taken into account when considering interruption versus continuation of antitumoral therapy. However, further data and studies are required.
在严重急性呼吸综合征冠状病毒 2 大流行期间，有几个患者群体面临特殊风险。癌症患者的死亡率较高，并且根据最近的出版物，血栓栓塞事件可能会进一步增加，而 2019 年冠状病毒患者中这种事件更为常见。我们通过报告一例病例研究并总结现有文献来讨论妇科恶性肿瘤、严重急性呼吸综合征冠状病毒 2 和血栓栓塞之间的关联。
一名 71 岁白人卵巢癌患者正在接受一线化疗，被诊断为深静脉血栓形成和肺栓塞。常规筛查显示，该患者在无特定症状的情况下感染了严重急性呼吸综合征冠状病毒 2。在康复后，几周后可以继续进行肿瘤治疗。
我们根据系统评价和荟萃分析的首选报告项目指南在 PubMed 上进行了系统文献回顾。搜索包括在 2019 年 12 月 1 日至 2020 年 6 月 1 日期间发表的预印本文章。对所有相关文章进行了交叉搜索。
我们确定了符合定义标准的五篇文章，包括两项回顾性研究、一篇综述、一份立场文件以及一封给编辑的信。
感染严重急性呼吸综合征冠状病毒 2 的癌症患者预后相对较差，这可能部分归因于血栓栓塞事件发生率较高。建议进行血栓预防，评分系统有助于早期发现。在感染严重急性呼吸综合征冠状病毒 2 的癌症患者中，在考虑中断或继续抗肿瘤治疗时，应考虑个体发生血栓栓塞事件的风险。但是，还需要进一步的数据和研究。
