Rosenberger Christian
Nephrology and Medical Intensive Care, Charité Universitaetsmedizin Berlin, Berlin, Germany.
Kidney Int. 2022 Apr;101(4):670-673. doi: 10.1016/j.kint.2022.01.015.
Class 3 semaphorins (SEMA3) are secreted glycoproteins with established roles in the developing brain, heart, and kidney. In this issue of Kidney International, Cai et al. show that in acutely injured kidneys, semaphorin isoform SEMA3C is expressed de novo in glomeruli and the nephron, secreted into the circulation, and excreted into the urine. Compelling evidence is provided for SEMA3C promoting microvascular permeability, kidney swelling, and acute injury. SEMA3C antagonism may be a treatment option for acute kidney injury.
3类信号素（SEMA3）是分泌型糖蛋白，在发育中的脑、心脏和肾脏中发挥既定作用。在本期《国际肾脏病杂志》中，蔡等人表明，在急性损伤的肾脏中，信号素异构体SEMA3C在肾小球和肾单位中从头表达，分泌到循环中，并排泄到尿液中。有令人信服的证据表明SEMA3C会促进微血管通透性、肾脏肿胀和急性损伤。抑制SEMA3C可能是急性肾损伤的一种治疗选择。
