致癌病毒感染与癌症进展中的氨基酸代谢：分子见解与临床意义。
Oncogenic viral infection and amino acid metabolism in cancer progression: Molecular insights and clinical implications.
机构信息
Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Department of Radiology, XiangYa Hospital, Central South University, Changsha 410078, China; NHC Key Laboratory of Carcinogenesis, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Department of Radiology, XiangYa Hospital, Central South University, Changsha 410078, China; NHC Key Laboratory of Carcinogenesis, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha 410078, China; National Clinical Research Center for Geriatric Disorders, XiangYa Hospital, Central South University, Changsha 410078, China; Molecular Imaging Research Center of Central South University, Changsha 410008, Hunan, China.
出版信息
Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188724. doi: 10.1016/j.bbcan.2022.188724. Epub 2022 Mar 18.
Viruses lack essential living system, so they must hijack host cell metabolism for its survival and reproduction. Interestingly, the metabolic reprogramming induced by oncovirus is critical for the malignant transformation. Amino acid can supply the source of nitrogen and carbon for biosynthesis or fulfill the energy requirement for the rapid growth of tumor cells. Amino acid metabolism caused by oncogenic viral infection often mirrors metabolic changes observed in cancer cells, such as glutamine addiction, asparagine dependence, arginine auxotrophy and active serine/ proline metabolism. In this review, we describe amino acid metabolism reprogramming in tumors. We also discuss how oncogenic viruses hijack amino acid metabolism in the stress status. Further research on the metabolic profile of virus-related cancers will not only provide new targets for tumor prevention and treatment, but novel diagnostic and therapeutic strategies as well.
病毒缺乏基本的生命系统，因此它们必须劫持宿主细胞的代谢来生存和繁殖。有趣的是，致癌病毒诱导的代谢重编程对于恶性转化至关重要。氨基酸可以为生物合成提供氮源和碳源，或者满足肿瘤细胞快速生长的能量需求。致癌病毒感染引起的氨基酸代谢通常反映了癌细胞中观察到的代谢变化，例如谷氨酰胺成瘾、天冬酰胺依赖性、精氨酸营养缺陷和活跃的丝氨酸/脯氨酸代谢。在这篇综述中，我们描述了肿瘤中的氨基酸代谢重编程。我们还讨论了致癌病毒如何在应激状态下劫持氨基酸代谢。对病毒相关癌症代谢特征的进一步研究不仅将为肿瘤的预防和治疗提供新的靶点，还将为诊断和治疗策略提供新的思路。
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