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根据年龄分层使用 NOBLADS 评分预测结肠憩室出血患者的内镜治疗。

Use of the NOBLADS Score to Predict Endoscopic Treatment in Patients with Colonic Diverticular Bleeding by Age Stratification.

机构信息

Department of Gastroenterology, St. Luke's International Hospital, Japan.

Department of Cardiovascular Medicine, The University of Tokyo Hospital, Japan.

出版信息

Intern Med. 2022 Oct 15;61(20):3009-3016. doi: 10.2169/internalmedicine.9202-21. Epub 2022 Mar 19.

Abstract

Objective A high NOBLADS score reflecting the severity of lower gastrointestinal bleeding contributes to the identification of stigmata of recent hemorrhage (SRH) in colonic diverticular bleeding (CDB). The burden of colonoscopy is particularly high in elderly patients; therefore, we investigated the utility of the NOBLADS score for managing CDB by age stratification. The NOBLADS score performance in SRH prediction was estimated by the area under the receiver operating characteristic calculation and a multiple logistic regression model. Methods This was a single-center, retrospective cohort study. Patients who underwent initial colonoscopy with CDB between April 2008 and December 2019 were divided into a young group (<65 years old) and an elderly group (≥65 years old). We further categorized patients according to colonoscopy findings as SRH-positive, with successful endoscopic hemostasis performance, and SRH-negative, with suspected CDB. The main outcome measure was successful SRH identification. Results Four-hundred and seventeen CDB patients were included, of whom 250 (60.0%) were elderly. There were 72 (43.1%) SRH-positive patients in the young group and 94 (37.6%) in the elderly group. The areas under the receiver operating characteristic curves of the NOBLADS score predicting SRH identification were 0.76, 0.71, and 0.81 for all ages, young patients, and elderly patients, respectively. A multiple logistic regression analysis showed that SRH identification was significantly associated with NOBLADS scores in both groups. Eighty-one patients (32.4%) scored ≥4 in the elderly group, and 60 of those were SRH-positive (74.1%). All 27 patients (10.8%) who scored ≥4 with extravasation on computed tomography were found to have SRH. Conclusion The NOBLADS score is useful for predicting SRH identification, especially in elderly patients.

摘要

目的

NOBLADS 评分较高反映了下消化道出血的严重程度,有助于识别结肠憩室出血(CDB)中的近期出血征象(SRH)。由于结肠镜检查在老年患者中的负担特别重;因此,我们通过年龄分层研究了 NOBLADS 评分在 CDB 管理中的效用。通过计算接受者操作特征曲线下面积和多因素逻辑回归模型来评估 NOBLADS 评分在 SRH 预测中的表现。

方法

这是一项单中心回顾性队列研究。2008 年 4 月至 2019 年 12 月期间,因 CDB 接受初次结肠镜检查的患者被分为年轻组(<65 岁)和老年组(≥65 岁)。我们根据结肠镜检查结果进一步将患者分为 SRH 阳性(有成功的内镜止血表现)和 SRH 阴性(疑似 CDB)。主要结局测量指标是成功识别 SRH。

结果

共纳入 417 例 CDB 患者,其中 250 例(60.0%)为老年患者。年轻组中 72 例(43.1%)为 SRH 阳性患者,老年组中 94 例(37.6%)为 SRH 阳性患者。NOBLADS 评分预测 SRH 识别的受试者工作特征曲线下面积在所有年龄、年轻患者和老年患者中分别为 0.76、0.71 和 0.81。多因素逻辑回归分析显示,两组中 SRH 识别均与 NOBLADS 评分显著相关。老年组中 81 例(32.4%)患者评分≥4,其中 60 例为 SRH 阳性(74.1%)。所有 27 例(10.8%)评分≥4 且 CT 检查有外渗的患者均发现有 SRH。

结论

NOBLADS 评分可用于预测 SRH 识别,尤其是在老年患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/345b/9646343/5125632c3812/1349-7235-61-3009-g001.jpg

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