微创处理的脂肪源性间充质基质细胞与骨关节炎：一项叙述性综述。
Minimally manipulated adipose derived mesenchymal stromal cells and osteoarthritis: A narrative review.
作者信息
Akkawi Ibrahim, Draghetti Maurizio, Zmerly Hassan
机构信息
Villa Erbosa Hospital 50/2, 40129, Bologna, Italy.
1. Orthopaedics and Traumatology Unit, Villa Erbosa Hospital, Bologna, Italy.
出版信息
Acta Biomed. 2022 Mar 14;93(1):e2022135. doi: 10.23750/abm.v93i1.11102.
Abstract
Human mesenchymal stromal cells (MSCs) have increasingly been used to treat osteoarthritis (OA) related pain and dysfunction, due to their capacity for regeneration and anti-inflammatory effects. Adipose-derived MSCs are characterized by their abundance, ease of access, easy isolation procedures, high lipoaspirate stromal cell production, quicker multiplication of cells, and less pain and morbidity during harvesting. These cells are typically enzymatically derived from adipose tissue but this technique has complicated regulatory problems. To address this problem, a new technique has been created to extract and process adipose tissue without expansion and the use of enzymes to produce autologous minimally manipulated adipose-derived MSCs. Recent studies have confirmed that this treatment is an effective and promising method for treating pain and improving joint function in patients affected by OA with a very low percentage of complications at short to mid-term follow-up.
摘要
人间充质基质细胞（MSCs）因其再生能力和抗炎作用，越来越多地被用于治疗骨关节炎（OA）相关的疼痛和功能障碍。脂肪来源的间充质干细胞具有丰富、易于获取、分离程序简单、脂肪抽吸物基质细胞产量高、细胞增殖快以及采集过程中疼痛和发病率低等特点。这些细胞通常通过酶法从脂肪组织中获取，但该技术存在复杂的监管问题。为了解决这一问题，人们创造了一种新技术，无需扩增和使用酶即可提取和处理脂肪组织，以生产自体最低限度操作的脂肪来源的间充质干细胞。最近的研究证实，这种治疗方法是一种有效且有前景的方法，可用于治疗OA患者的疼痛并改善关节功能，在短期至中期随访中并发症发生率极低。
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