Tripathi Shambhoo Sharan, Kumar Raushan, Bissoyi Akalabya, Rizvi Syed Ibrahim
Department of Biochemistry, University of Allahabad, Allahabad, India.
Department of Biochemistry, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel.
Rejuvenation Res. 2022 Apr;25(2):70-78. doi: 10.1089/rej.2021.0071.
Caloric restriction (CR) is the most effective intervention for extending the life span of vertebrate and invertebrate aging models. Calorie restriction mimetics (CRMs), which are synthetic or natural chemicals that mimic the biochemical, hormonal, and physiological consequences of calorie restriction, are being researched for antiaging benefits. Baicalein is a plant-derived polyphenol that has the potential of antioxidant, anti-inflammatory, and autophagy inducer. The objective of this study is to evaluate the antiaging, anti-inflammatory, and antioxidant role of Baicalein in erythrocyte membrane and plasma, and evaluate the efficacy of Baicalein to act as a CRM candidate. This study evaluates the effect of Baicalein on aging biomarkers in normal and aged rats. We study various pro- and antioxidant markers, erythrocyte membrane transporters, and eryptosis. Baicalein supplementation in male Wistar rats significantly alleviated pro-oxidant markers and improved antioxidant profile. Improvement was also observed in age-induced alterations in membrane transporters, and eryptosis. Based on the aforementioned observations we conclude that Baicalein has the potential to maintain extracellular reactive oxygen species levels and redox homeostasis during the aging process, an effect that is similar to CR. Thus, Baicalein may be a potent CRM candidate for antiaging interventions.
热量限制（CR）是延长脊椎动物和无脊椎动物衰老模型寿命最有效的干预措施。热量限制模拟物（CRM）是一类合成或天然的化学物质，可模拟热量限制的生化、激素和生理效应，目前正在研究其抗衰老益处。黄芩素是一种植物来源的多酚，具有抗氧化、抗炎和诱导自噬的潜力。本研究的目的是评估黄芩素在红细胞膜和血浆中的抗衰老、抗炎和抗氧化作用，并评估黄芩素作为CRM候选物的功效。本研究评估了黄芩素对正常和老年大鼠衰老生物标志物的影响。我们研究了各种促氧化和抗氧化标志物、红细胞膜转运蛋白和红细胞凋亡。雄性Wistar大鼠补充黄芩素可显著减轻促氧化标志物并改善抗氧化状态。在膜转运蛋白和红细胞凋亡的年龄诱导变化中也观察到了改善。基于上述观察结果，我们得出结论，黄芩素有可能在衰老过程中维持细胞外活性氧水平和氧化还原稳态，这一作用类似于热量限制。因此，黄芩素可能是抗衰老干预的一种有效CRM候选物。
