Singh Sandeep, Garg Geetika, Singh Abhishek Kumar, Tripathi Shambhoo Sharan, Rizvi Syed Ibrahim
Department of Biochemistry, University of Allahabad, Allahabad, India.
Amity Institute of Neuropsychology and Neurosciences, Amity University Uttar Pradesh, Noida, India.
Arch Physiol Biochem. 2022 Feb;128(1):51-58. doi: 10.1080/13813455.2019.1662452. Epub 2019 Sep 9.
Fisetin as a caloric restriction mimetic (CRM) exerts numerous beneficial effects on different aging model systems. The effect of fisetin on erythrocyte membrane functions against induced aging is not very clear.
The potential role of fisetin in the modulation of erythrocytes membrane-bound transporters during natural and induced aging in rats was assessed.
Male Wistar rats were used for natural and D-galactose (D-gal) induced aging model. After supplementation with fisetin, the activities of different membrane transporters and biomarkers of oxidative stress were evaluated.
Fisetin modulated membrane transporters such as calcium-ATPase, sodium potassium-ATPase and sodium hydrogen exchanger during senescence-induced as well as in natural aging. Fisetin also protected oxidative modifications in rat aging.
Fisetin supplementation improves the ionic homeostasis, a factor that is involved in the aetiology of several age-associated diseases, in naturally old as well as D-gal induced aged rats.
漆黄素作为一种热量限制模拟物（CRM），对不同的衰老模型系统具有多种有益作用。漆黄素对诱导衰老的红细胞膜功能的影响尚不清楚。
评估漆黄素在大鼠自然衰老和诱导衰老过程中对红细胞膜结合转运蛋白的潜在调节作用。
雄性Wistar大鼠用于建立自然衰老和D-半乳糖（D-gal）诱导的衰老模型。补充漆黄素后，评估不同膜转运蛋白的活性和氧化应激生物标志物。
漆黄素在衰老诱导以及自然衰老过程中调节膜转运蛋白，如钙-ATP酶、钠钾-ATP酶和钠氢交换体。漆黄素还能保护大鼠衰老过程中的氧化修饰。
补充漆黄素可改善自然衰老以及D-gal诱导的衰老大鼠的离子稳态，而离子稳态是多种与年龄相关疾病病因中的一个因素。
