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瘤内注射博来霉素治疗免疫功能低下患者的顽固性疣：一种安全、有效但未得到充分利用的疗法。

Intralesional bleomycin for treatment of a recalcitrant wart in an immunocompromised patient: A safe, effective, and underutilized therapy.

作者信息

Ngo Tracy, Hwang Hannah, Amin Bijal, Cohen Steven R

机构信息

Albert Einstein College of Medicine Bronx New York USA.

Division of Dermatology Albert Einstein College of Medicine Bronx New York USA.

出版信息

Clin Case Rep. 2022 Mar 16;10(3):e05613. doi: 10.1002/ccr3.5613. eCollection 2022 Mar.

DOI:10.1002/ccr3.5613
PMID:35317064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8924998/
Abstract

Injectable bleomycin is infrequently used for recalcitrant warts despite its efficacy, acceptable safety profile, and high patient satisfaction compared with other treatment modalities. We present an immunocompromised patient with a large recalcitrant wart successfully treated with intralesional bleomycin to provide greater clinical exposure, training, and practice with intralesional bleomycin.

摘要

尽管注射用博来霉素与其他治疗方式相比疗效显著、安全性良好且患者满意度高，但这种药物在治疗顽固性疣时并不常用。我们报告了一例免疫功能低下的患者，其患有巨大顽固性疣，通过病灶内注射博来霉素成功治愈，旨在提供更多关于病灶内注射博来霉素的临床经验、培训及实践案例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0140/8924998/fe46e2769716/CCR3-10-e05613-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0140/8924998/fe46e2769716/CCR3-10-e05613-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0140/8924998/fe46e2769716/CCR3-10-e05613-g001.jpg

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1
Intralesional bleomycin for treatment of a recalcitrant wart in an immunocompromised patient: A safe, effective, and underutilized therapy.瘤内注射博来霉素治疗免疫功能低下患者的顽固性疣：一种安全、有效但未得到充分利用的疗法。
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本文引用的文献

1
Intralesional Bleomycin for Warts: Patient Satisfaction and Treatment Outcomes.皮损内注射博来霉素治疗疣：患者满意度及治疗效果
J Cutan Med Surg. 2015 Sep-Oct;19(5):470-6. doi: 10.1177/1203475415576860. Epub 2015 Mar 18.
2
Treatment of cutaneous warts: an evidence-based review.皮肤疣的治疗：基于证据的综述。
Am J Clin Dermatol. 2012 Apr 1;13(2):73-96. doi: 10.2165/11594610-000000000-00000.
3
Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris.足底疣病灶内注射博来霉素后出现鞭毛虫样色素沉着。
Arch Dermatol. 2003 Mar;139(3):337-9. doi: 10.1001/archderm.139.3.337.
4
Histologic, pharmacologic, and immunocytochemical effects of injection of bleomycin into viral warts.向病毒疣内注射博来霉素的组织学、药理学及免疫细胞化学效应
J Am Acad Dermatol. 1993 Jun;28(6):933-7. doi: 10.1016/0190-9622(93)70133-e.
5
Bleomycin in the treatment of recalcitrant warts.博来霉素治疗顽固性疣
J Am Acad Dermatol. 1983 Jul;9(1):91-6. doi: 10.1016/s0190-9622(83)70112-x.
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Therapeutic evaluation for intralesional injection of bleomycin sulfate in 143 resistant warts.
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7
Reduced dose of bleomycin in the treatment of recalcitrant warts.降低剂量的博来霉素治疗顽固性疣
J Am Acad Dermatol. 1986 Nov;15(5 Pt 1):1002-6. doi: 10.1016/s0190-9622(86)70264-8.