Hayes M E, O'Keefe E J
J Am Acad Dermatol. 1986 Nov;15(5 Pt 1):1002-6. doi: 10.1016/s0190-9622(86)70264-8.
The effectiveness of intralesional bleomycin (1 U/ml) in the treatment of warts refractory to conventional methods of treatment has been shown in well-controlled studies. We have now evaluated more dilute concentrations of bleomycin in the treatment of recalcitrant warts. Warts were assigned for therapy with intralesional bleomycin at a concentration of 0.25 U/ml, 0.5 U/ml, or 1 U/ml at 3-week intervals. If warts persisted after three injections or had recurred by 3 months' follow-up, treatment was considered a failure. Twenty-six patients whose warts had persisted after conventional treatment entered the study. Three patients had spontaneous regression of untreated warts during therapy and were not included in the results. Of seventy-nine warts treated with intralesional bleomycin, sixty-two (78%) were cured after one to three injections. Responding warts showed a hemorrhagic eschar even with the lower bleomycin concentrations and healed without complication. Almost all treated warts responded, although not all were cured. Treatment with bleomycin at 0.5 U/ml was as effective as treatment with 1 U/ml. Bleomycin at 0.25 U/ml is effective therapy but not enough warts were treated to permit a conclusion when compared with higher concentrations.
在严格对照的研究中已表明，病灶内注射博来霉素（1单位/毫升）治疗对传统治疗方法无效的疣是有效的。我们现在评估了更稀释浓度的博来霉素治疗顽固性疣的效果。将疣每隔3周分别用浓度为0.25单位/毫升、0.5单位/毫升或1单位/毫升的病灶内博来霉素进行治疗。如果三次注射后疣仍持续存在或在3个月随访时复发，则治疗被视为失败。26例经传统治疗后疣仍持续存在的患者进入该研究。3例患者在治疗期间未治疗的疣自发消退，未纳入结果分析。在接受病灶内博来霉素治疗的79个疣中，62个（78%）在1至3次注射后治愈。即使使用较低浓度的博来霉素，有反应的疣也会出现出血性焦痂，且愈合无并发症。几乎所有接受治疗的疣都有反应，尽管并非全部治愈。0.5单位/毫升的博来霉素治疗效果与1单位/毫升的相同。0.25单位/毫升的博来霉素是有效的治疗方法，但与较高浓度相比，接受治疗的疣数量不足，无法得出结论。
