Kaan Demircioglu Mahmut, Gul Demircioglu Zeynep, Aygun Nurcihan, Yilmaz Ozguven Banu, Ethem Akgun Ismail, Uludag Mehmet
Department of General Surgery, Kars Harakani State Hospital, Kars, Turkey.
Department of General Surgery, University of Health Sciences Turkey, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
Sisli Etfal Hastan Tip Bul. 2021 Dec 29;55(4):510-515. doi: 10.14744/SEMB.2021.45202. eCollection 2021.
Vitamin D deficiency is a very common global health problem. Evidence from recent studies focuses on the extraskeletal effects of vitamin D (Vit D) deficiency. Chronic lymphocytic thyroiditis (or Hashimoto's thyroiditis) is an autoimmune disease of the thyroid. Although there are many studies reporting that autoimmune thyroid diseases may be associated with Vitamin D deficiency, this is still a controversial issue that has not yet been proven. In this study, we aimed to appraise whether there is a relationship between lymphocytic thyroiditis diagnosed by histopathological evaluation and Vitamin D deficiency.
Data of 256 patients whom were operated by a single surgeon in a single center between 2012 and 2017 and whose preoperative vitamin D tests and thyroid pathologies have been collected, were retrospectively evaluated. Due to the pathological examination, two groups were formed considering the presence of lymphocytic thyroiditis (Group 1), and the absence of lymphocytic thyroiditis (Group 2). Vitamin D deficiency was defined as the level <20 ng/mL (50 nmol/L) and Vitamin D insufficiency was defined as the level 21-29 ng/mL (525-725 nmol/L).
There were 108 (92F/16M) patients in Group 1, and 148 (116F/32M) patients in Group 2, and the mean age was lower in Group 1 (p=0.053). The mean vitamin D levels (16.6±15.2 vs. 14±10, p=0.409) and vitamin D deficiency rates (67.6% vs. 72.3%, p=0.416) were found similar between the Groups 1 and 2. No positive significant correlation was found between lymphocytic thyroiditis and vitamin D level or vitamin D deficiency rates. There was a positive correlation between lymphocytic thyroiditis and age, preoperative thyroid-stimulating hormone level, preoperative anti-thyroglobulin ,and anti-thyroid peroxidase levels, but no significant relationship was found with Vitamin D level.
According to our results, lymphocytic thyroiditis was not associated with either Vitamin D deficiency or Vitamin D level.
维生素D缺乏是一个非常常见的全球健康问题。近期研究证据聚焦于维生素D（Vit D）缺乏的骨骼外影响。慢性淋巴细胞性甲状腺炎（或桥本甲状腺炎）是一种甲状腺自身免疫性疾病。尽管有许多研究报告称自身免疫性甲状腺疾病可能与维生素D缺乏有关，但这仍是一个尚未得到证实的有争议的问题。在本研究中，我们旨在评估经组织病理学评估诊断的淋巴细胞性甲状腺炎与维生素D缺乏之间是否存在关联。
回顾性评估2012年至2017年间在单一中心由单一外科医生进行手术且收集了术前维生素D检测结果和甲状腺病理资料的256例患者的数据。根据病理检查，考虑淋巴细胞性甲状腺炎的存在（第1组）和不存在淋巴细胞性甲状腺炎（第2组）形成两组。维生素D缺乏定义为水平<20 ng/mL（50 nmol/L），维生素D不足定义为水平21 - 29 ng/mL（525 - 725 nmol/L）。
第1组有108例患者（92例女性/16例男性），第2组有148例患者（116例女性/32例男性），第1组的平均年龄较低（p = 0.053）。第1组和第2组之间的平均维生素D水平（16.6±15.2 vs. 14±10，p = 0.409）和维生素D缺乏率（67.6% vs. 72.3%，p = 0.416）相似。未发现淋巴细胞性甲状腺炎与维生素D水平或维生素D缺乏率之间存在显著正相关。淋巴细胞性甲状腺炎与年龄、术前促甲状腺激素水平、术前抗甲状腺球蛋白和抗甲状腺过氧化物酶水平之间存在正相关，但与维生素D水平未发现显著关系。
根据我们的结果，淋巴细胞性甲状腺炎与维生素D缺乏或维生素D水平均无关联。
