维生素 D 在甲状腺疾病中的作用。
The Role of Vitamin D in Thyroid Diseases.
机构信息
Division of Endocrinology, Department of Internal Medicine, Dankook University College of Medicine, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 330-714, Korea.
Department of Kinesiologic Medical Science, Graduate, Dankook University, Cheonan 330-714, Korea.
出版信息
Int J Mol Sci. 2017 Sep 12;18(9):1949. doi: 10.3390/ijms18091949.
Abstract
The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause mortality. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease, and impaired vitamin D signaling has been reported in thyroid cancers. This review will focus on recent data on the possible role of vitamin D in thyroid diseases, including autoimmune thyroid diseases and thyroid cancers.
摘要
维生素 D 的主要作用是调节骨骼代谢和钙磷稳态。在过去的几十年中，人们研究了维生素 D 在非骨骼作用中的重要性，包括维生素 D 在自身免疫性疾病、代谢综合征、心血管疾病、癌症和全因死亡率中的作用。最近的证据表明，维生素 D 状态低下与自身免疫性甲状腺疾病（如桥本甲状腺炎和格雷夫斯病）之间存在关联，并且在甲状腺癌中已经报道了维生素 D 信号转导受损。本综述将重点介绍维生素 D 可能在甲状腺疾病（包括自身免疫性甲状腺疾病和甲状腺癌）中的作用的最新数据。
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