Wang Rong-Fei, Hong Yong-Gang, Hao Li-Qiang, Yu Hai-Tao
Department of Tumor, Anus and Intestine, Jinhua People's Hospital, Jinhua, Zhejiang 321000, P.R. China.
Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China.
Exp Ther Med. 2022 Apr;23(4):286. doi: 10.3892/etm.2022.11215. Epub 2022 Feb 15.
Colorectal cancer (CRC) is the third most common cancer type and one of the deadliest cancers worldwide. Transmembrane p24 trafficking protein 3 (TMED3) has previously been indicated to suppress CRC metastasis, but its clinical significance has remained undetermined. In the present study, the expression of TMED3 was indicated to be elevated at the mRNA and protein levels in CRC tumor samples relative to that in para-cancerous healthy tissue samples (P<0.05). Furthermore, Kaplan-Meier survival analysis revealed a significant negative association between elevated TMED3 protein levels and overall survival of patients with CRC (P<0.001, log-rank test). Multivariate Cox regression analysis additionally determined that elevated TMED3 expression in primary CRC tumors was an independent predictor of poor prognosis (P<0.05). These results revealed that elevated TMED3 expression in CRC was associated with patient survival outcomes, suggesting that TMED3 may be a potential prognostic biomarker for this cancer type.
结直肠癌（CRC）是全球第三大常见癌症类型，也是最致命的癌症之一。跨膜p24转运蛋白3（TMED3）此前已被证明可抑制结直肠癌转移，但其临床意义仍未明确。在本研究中，相对于癌旁健康组织样本，结直肠癌肿瘤样本中TMED3在mRNA和蛋白质水平的表达均升高（P<0.05）。此外，Kaplan-Meier生存分析显示，TMED3蛋白水平升高与结直肠癌患者的总生存期之间存在显著负相关（P<0.001，对数秩检验）。多变量Cox回归分析还确定，原发性结直肠癌肿瘤中TMED3表达升高是预后不良的独立预测因素（P<0.05）。这些结果表明，结直肠癌中TMED3表达升高与患者生存结果相关，提示TMED3可能是这种癌症类型的潜在预后生物标志物。
