Department of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Cosmet Dermatol. 2022 Oct;21(10):4510-4514. doi: 10.1111/jocd.14931. Epub 2022 Apr 24.
Alopecia areata is a common non-scarring alopecia, mainly manifested as sudden localized patchy alopecia. It is currently believed to be related to autoimmune, genetic, emotional stress, and endocrine factors.
The aim of this study was to evaluate the efficacy and safety of the mixed preparation of piperine, capsaicin, and curcumin on alopecia areata treatment.
Sixty patients were enrolled in this study and divided into 2 groups randomly: topical treated with the mixed preparation (case) twice daily and 5%minoxidil (control) once daily for 3 months. The degree of hair loss was assessed by SALT and dermoscopy.
On the completion of the study, compared with baseline, statistically significant regrowth occurred in both groups (p < 0.05). The mean SALT scores and hair follicle status under trichoscopy at baseline and at the end of 12 weeks in the mixed preparation group and in the minoxidil group were comparable, respectively. The effective rate of mixed preparation group was 63.33% and minoxidil group was 70%. Adverse symptoms were temporary and no serious adverse event occurred.
Based on our findings, the mixed preparation of piperine, capsaicin, and curcumin is effective in treating alopecia areata, but it has not been shown to be superior to minoxidil in short-term therapy.
斑秃是一种常见的非瘢痕性脱发，主要表现为突然发生的局限性斑片状脱发。目前认为其与自身免疫、遗传、情绪应激和内分泌因素有关。
本研究旨在评估胡椒碱、辣椒素和姜黄素混合制剂治疗斑秃的疗效和安全性。
本研究纳入 60 例患者，随机分为两组：局部每日两次使用混合制剂（病例组）和每日一次使用 5%米诺地尔（对照组），治疗 3 个月。采用 SALT 和皮肤镜评估脱发程度。
研究完成时，与基线相比，两组均出现了统计学意义上的显著再生（p<0.05）。混合制剂组和米诺地尔组在基线和 12 周结束时的平均 SALT 评分和毛发镜下毛囊状态相当。混合制剂组的有效率为 63.33%，米诺地尔组为 70%。不良反应为暂时性，未发生严重不良事件。
根据我们的发现，胡椒碱、辣椒素和姜黄素的混合制剂治疗斑秃有效，但在短期治疗中并未显示优于米诺地尔。
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