从全株菝葜中分离得到的 3 个新化合物。

Three new compounds isolated from the whole plants of pall.

机构信息

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P. R. China.

Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, P. R. China.

出版信息

Nat Prod Res. 2023 Jul-Aug;37(15):2551-2558. doi: 10.1080/14786419.2022.2055556. Epub 2022 Mar 23.

DOI:10.1080/14786419.2022.2055556

PMID:35319320

Abstract

One new alkaloid, 6, 7-dimethoxyisoquinoline--oxide (), one new benzofuran derivative, 3,7-dimethyl-6-acetyl-8-benzofuranol () and one new lignan, salsolains A (), along with seven known compounds (-), were isolated from the whole plant of Pall. Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HR-ESI-MS, 1 D and 2 D NMR), and their absolute configurations were determined by the X-ray crystallography and ECD calculation. The activities of compounds - against inflammatory cytokines IL-6 and TNF- levels on LPS-induced RAW 264.7 macrophages were assessed, especially, compound (50 μM) exhibited the most significant anti-inflammatory activity with the secretion levels of IL-6 and TNF- at 3.87% and 4.03%, respectively.

摘要

从 Pall 的全株植物中分离得到一个新的生物碱，6,7-二甲氧基异喹啉-氧化物 ()，一个新的苯并呋喃衍生物，3,7-二甲基-6-乙酰基-8-苯并呋喃醇 () 和一个新的木脂素，salsolains A ()，以及七个已知化合物 (-)。通过对光谱数据（IR、UV、HR-ESI-MS、1D 和 2D NMR）的广泛分析，阐明了它们的结构，并通过 X 射线晶体学和 ECD 计算确定了它们的绝对构型。评估了化合物 - 对 LPS 诱导的 RAW 264.7 巨噬细胞中炎症细胞因子 IL-6 和 TNF-水平的活性，特别是化合物（50 μM）表现出最显著的抗炎活性，IL-6 和 TNF-的分泌水平分别为 3.87%和 4.03%。