Khosravifar Mina, Sajadimajd Soraya, Bahrami Gholamreza
Student Research Committee, School of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran.
Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran.
Curr Mol Med. 2023;23(3):250-265. doi: 10.2174/1566524022666220321125548.
Diabetes is a major global health concern, manifesting the symptoms of chronic hyperglycemia. Either insufficient or excessive angiogenesis is generally involved in the pathogenesis of diabetes and its complications.
Given that macronutrients are important dietary players in global health issues, we aimed to review the role of macronutrients, including carbohydrates and proteins, to manage diabetes via angiogenesis modulation.
Sixteen studies regarding the effects of macronutrients, including carbohydrates and proteins derived from plants, fungus, bacteria, and their derivatives, on angiogenesis in diabetes were included in our study.
Reviewing these studies suggests that carbohydrates, including low molecular weight fucoidan (LMWF), Astragalus polysaccharide (APS), and Ganoderma lucidum polysaccharide (Gl-PS), as well as oligopeptides, like sea cucumber-isolated small molecule oligopeptides (SCCOPs), can induce angiogenesis in the process of wound healing. Considering retinopathy, carbohydrates, including Diphlorethohydroxycarmalol (DPHC), Lyciumbarbarum (LBP), Sulfated K5 Escherichia coli polysaccharide (K5-N, OS (H)), and carnosine suppressed retinal angiogenesis. Furthermore, rice bran protein (RBP) ameliorated angiogenesis in diabetic nephropathy. Carbohydrates, including DPHC, Anoectochilus roxburghii polysaccharide (ARP), and LMWF, showed beneficial effects on endothelial cell dysfunction.
In conclusion, data suggest that a number of macronutrients, including proteins and carbohydrates, could have protective effects against complications of diabetes via modulation of angiogenesis.
糖尿病是一个重大的全球健康问题，表现为慢性高血糖症状。血管生成不足或过度通常都参与糖尿病及其并发症的发病机制。
鉴于常量营养素在全球健康问题中是重要的饮食因素，我们旨在综述包括碳水化合物和蛋白质在内的常量营养素通过调节血管生成来控制糖尿病的作用。
我们的研究纳入了16项关于常量营养素（包括来自植物、真菌、细菌及其衍生物的碳水化合物和蛋白质）对糖尿病血管生成影响的研究。
回顾这些研究表明，碳水化合物，包括低分子量岩藻多糖（LMWF）、黄芪多糖（APS）和灵芝多糖（Gl-PS），以及寡肽，如海参分离的小分子寡肽（SCCOPs），可在伤口愈合过程中诱导血管生成。考虑到视网膜病变，碳水化合物，包括二氢羟基卡拉酚（DPHC）、枸杞（LBP）、硫酸化大肠杆菌K5多糖（K5-N，OS（H））和肌肽可抑制视网膜血管生成。此外，米糠蛋白（RBP）改善了糖尿病肾病中的血管生成。碳水化合物，包括DPHC、金线莲多糖（ARP）和LMWF，对内皮细胞功能障碍显示出有益作用。
总之，数据表明，包括蛋白质和碳水化合物在内的多种常量营养素可通过调节血管生成对糖尿病并发症产生保护作用。
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