Thomas M R, Robinson W A, Mughal T I, Morton N, Glode L M
Oncology. 1986;43(5):273-7. doi: 10.1159/000226381.
Sixteen patients with advanced (stage III) malignant melanoma were treated with escalating doses of intravenous BCNU and melphalan starting at 400 and 35 mg/m2, respectively, and escalating to 1,000 and 110 mg/m2, respectively, combined with autologous marrow transplantation. The duration of granulocytopenia and time to granulocyte recovery was similar in all groups regardless of chemotherapy dose. Platelet recovery was delayed in patients receiving the highest doses of chemotherapy. This study showed that bone marrow colony-forming units in culture took as long as 6 months to recover. This was adequate to bring peripheral blood counts to normal but not to pretreatment levels. These studies indicate that autologous bone marrow transplantation is beneficial in enhancing short-term recovery, but may not be beneficial in the long-term hematopoietic recovery.
16例晚期（III期）恶性黑色素瘤患者接受了递增剂量的静脉注射卡莫司汀（BCNU）和美法仑治疗，起始剂量分别为400mg/m²和35mg/m²，分别递增至1000mg/m²和110mg/m²，并联合自体骨髓移植。无论化疗剂量如何，所有组的粒细胞减少持续时间和粒细胞恢复时间相似。接受最高剂量化疗的患者血小板恢复延迟。这项研究表明，培养中的骨髓集落形成单位需要长达6个月才能恢复。这足以使外周血细胞计数恢复正常，但无法恢复到预处理水平。这些研究表明，自体骨髓移植有利于促进短期恢复，但对长期造血恢复可能无益处。
