表面之下：一例接受派姆单抗治疗的转移性虹膜睫状体环黑色素瘤病例报告。

Beneath the surface: a case report of metastatic iridociliary ring melanoma treated with pembrolizumab.

机构信息

Ocular Oncology Service, Institute of Ophthalmology and Visual Sciences, Tecnologico de Monterrey, Monterrey, Mexico.

Uveitis and Ocular Inflammation Service, Clínica Oftalmológica Santa Lucía, Guadalajara, Jalisco, Mexico.

出版信息

Arq Bras Oftalmol. 2024 Jan 22;86(5):e20230046. doi: 10.5935/0004-2749.20230046. eCollection 2024.

DOI:10.5935/0004-2749.20230046

PMID:35319657

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11826537/

Abstract

Iridociliary ring melanoma is an uncommon type of uveal melanoma. Clinical manifestation varies from asymptomatic cases to masquerade syndromes mimicking refractory glaucoma. Treatment options include radiotherapy and enucleation. Management of metastatic uveal melanoma remains discouraging. Novel therapies using immune checkpoint inhibitors are currently under study. We present a case of a 54-year-old Hispanic woman with progressive vision loss due to metastatic ring melanoma with anterior chamber seeding treated with pembrolizumab.

摘要

虹膜睫状体黑色素瘤是一种罕见的葡萄膜黑色素瘤。临床表现从无症状病例到模仿难治性青光眼的伪装综合征不等。治疗选择包括放射治疗和眼球摘除术。转移性葡萄膜黑色素瘤的治疗仍然令人沮丧。目前正在研究使用免疫检查点抑制剂的新疗法。我们报告了一例 54 岁的西班牙裔女性，因转移性环形黑色素瘤伴前房播散导致视力进行性下降，接受了 pembrolizumab 治疗。