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巴西老年人中苯二氮䓬类药物的使用情况:一项基于人群的研究。

Benzodiazepines utilization in Brazilian older adults: a population-based study.

机构信息

Universidade Federal de Pelotas . Faculdade de Medicina . Programa de Pós-Graduação em Epidemiologia . Pelotas , RS , Brasil.

Universidade Federal de Pelotas . Faculdade de Medicina . Departamento de Medicina Social . Pelotas , RS , Brasil.

出版信息

Rev Saude Publica. 2022 Mar 21;56:10. doi: 10.11606/s1518-8787.2022056003740. eCollection 2022.

Abstract

OBJECTIVE

To evaluate the utilization of benzodiazepines (BZD) in Brazilian older adults, based on the Pesquisa Nacional de Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey of Access, Use and Promotion of Rational Use of Medicines).

METHODS

The PNAUM is a cross-sectional study conducted between 2013 and 2014, representing the Brazilian urban population. In the present study, we included 60 years or older (n = 9,019) individuals. We calculated the prevalence of BZD utilization in the 15 days prior to survey data collection according to independent variables, using a hierarchical Poisson regression model. A semistructured interview performed empirical data collection (household interview).

RESULTS

The prevalence of BZD utilization in the older adults was 9.3% (95%CI: 8.3-10.4). After adjustments, BZD utilization was associated with female sex (PR = 1.88; 95%CI: 1.52-2.32), depression (PR = 5.31; 95%CI: 4.41-6, 38), multimorbidity (PR = 1.44; 95%CI: 1.20-1.73), emergency room visit or hospitalization in the last 12 months (PR = 1.42; 95%CI: 1.18-1.70 ), polypharmacy (PR = 1.26; 95%CI: 1.01-1.57) and poor or very poor self-rated health (PR = 4.16; 95%CI: 2.10-8.22). Utilization was lower in the North region (PR = 0.18; 95%CI: 0.13-0.27) and in individuals who reported abusive alcohol consumption in the last month (PR = 0.42; 95%CI: 0.19-0.94).

CONCLUSION

Despite contraindications, results showed a high prevalence of BZD utilization in older adults, particularly in those with depression, and wide regional and sex differences.

摘要

目的

基于巴西全国药品获得、使用和促进合理用药调查(PNAUM),评估巴西老年人使用苯二氮䓬类药物(BZD)的情况。

方法

PNAUM 是一项于 2013 年至 2014 年开展的、代表巴西城市人口的横断面研究。本研究纳入 60 岁及以上(n=9019)人群。我们根据独立变量计算了调查数据收集前 15 天内 BZD 的使用率,使用分层泊松回归模型进行分析。半结构式访谈进行了实证数据收集(家庭访谈)。

结果

老年人 BZD 的使用率为 9.3%(95%CI:8.3-10.4)。调整后,BZD 的使用与女性(PR=1.88;95%CI:1.52-2.32)、抑郁(PR=5.31;95%CI:4.41-6.38)、多种疾病(PR=1.44;95%CI:1.20-1.73)、过去 12 个月内急诊或住院(PR=1.42;95%CI:1.18-1.70)、多种药物治疗(PR=1.26;95%CI:1.01-1.57)和自我报告健康状况较差或非常差(PR=4.16;95%CI:2.10-8.22)相关。在北部地区(PR=0.18;95%CI:0.13-0.27)和报告过去一个月内滥用酒精的个体(PR=0.42;95%CI:0.19-0.94)中,BZD 的使用率较低。

结论

尽管存在禁忌证,但结果显示,巴西老年人 BZD 的使用率较高,特别是在患有抑郁的老年人中,且存在广泛的地区和性别差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ae9/8926397/08bf1b991023/1518-8787-rsp-56-10-gf01.jpg

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