Azevedo Ângelo José Pimentel de, Araújo Aurigena Antunes de, Ferreira Maria Ângela Fernandes
Pós-Graduação em Saúde Coletiva, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil,
Departamento de Biofísica e Farmacologia, Centro de Biociências, UFRN, Brasil.
Cien Saude Colet. 2016 Jan;21(1):83-90. doi: 10.1590/1413-81232015211.15532014.
The scope of this article is to determine the distribution and frequency of consumption of anxiolytic benzodiazepines and the correlation between consumption and demographic, epidemiological, economic and social characteristics. It is an ecological study with a sample of 27 state capitals. Data collection was performed through the ANVISA database for the dispensation of Alprazolam, Bromazepam, Clonazepam, Diazepam and Lorazepam in 2010-2012, the 2010 Demographic Census (IBGE), DATASUS and Medical Demographic Research. Descriptive statistical analysis and multiple linear regression analyses were performed for data analysis. The northern region has capitals with the lowest and the southeast has capitals with the highest average consumption of these products. The average consumption for the population of all capitals was 3.60 DHD. Alprazolam is the drug most dispensed by pharmacies and private drugstores with average 2.00 DHD for the capitals. Multiple linear regression analysis showed that 76% of the variation was explained by population density (β = 0.310 p = 0.045) and percentage of physicians (β = 0.507 p = 0.016). The consumption of short half-life anxiolytics has been on the increase, mainly in the cities of greater population density and concentration of physicians.
本文的范围是确定抗焦虑苯二氮䓬类药物的消费分布和频率,以及消费与人口、流行病学、经济和社会特征之间的相关性。这是一项以27个州首府为样本的生态学研究。通过巴西国家卫生监督局(ANVISA)数据库收集2010 - 2012年阿普唑仑、溴西泮、氯硝西泮、地西泮和劳拉西泮的配药数据、2010年人口普查(巴西地理与统计研究所,IBGE)、巴西卫生部综合卫生系统数据库(DATASUS)以及医学人口研究数据。数据分析采用描述性统计分析和多元线性回归分析。北部地区首府这些产品的平均消费量最低,东南部地区首府的平均消费量最高。所有首府人口的平均消费量为3.60 DHD。阿普唑仑是药房和私人药店配药最多的药物,首府的平均配药量为2.00 DHD。多元线性回归分析表明,76%的变异可由人口密度(β = 0.310,p = 0.045)和医生比例(β = 0.507,p = 0.016)解释。短半衰期抗焦虑药物的消费量一直在增加,主要集中在人口密度较大且医生集中的城市。