Singsen B H
Pediatr Clin North Am. 1986 Oct;33(5):1119-39. doi: 10.1016/s0031-3955(16)36111-9.
Scleroderma is a rare disease in children. Heterogeneous in its many forms, it ranges from circumscribed and self-limited pigmentary disorders to disabling and disfiguring involvement of an extremity. It also may include diffuse skin disease, multiple internal organ derangements, and a rapidly fatal outcome. Outcome varies widely and is related to the location and extent of cutaneous involvement, evaluation of disfigurement or impairment, and which treatment resources are available.
硬皮病在儿童中是一种罕见疾病。其形式多样，从局限性和自限性色素沉着紊乱到导致肢体残疾和毁容的病变不等。它还可能包括弥漫性皮肤病、多个内脏器官紊乱以及迅速致命的后果。预后差异很大，与皮肤受累的部位和程度、毁容或功能损害的评估以及可获得的治疗资源有关。
