Black C M
Royal Free Hospital, London, UK.
Curr Opin Rheumatol. 1995 Sep;7(5):442-8. doi: 10.1097/00002281-199509000-00014.
Scleroderma is a spectrum of disorders, all of which may occur in childhood. Childhood disease differs from adult disease in that localized forms predominate, with major problems confined to the skin and underlying soft tissues; generalized scleroderma, whether diffuse or limited, is less common. Childhood eosinophilic fasciitis is rare, and the literature is scant. The pattern appears to be similar to that in adults, and as in the adult form, the overlap between eosinophilic fasciitis, morphea, and linear scleroderma is blurred. The etiopathogenesis of juvenile-onset scleroderma is unknown but almost certainly multifactorial. The heterogeneity of its clinical expression may argue for it being more than one disease. This review attempts to document the expression of scleroderma in childhood and relate it to etiologic, immunologic, and pathogenic considerations.
硬皮病是一系列疾病，所有这些疾病都可能在儿童期出现。儿童期疾病与成人期疾病的不同之处在于，局部性形式占主导，主要问题局限于皮肤和皮下软组织；全身性硬皮病，无论是弥漫性还是局限性，都较少见。儿童嗜酸性筋膜炎罕见，相关文献也很少。其表现模式似乎与成人相似，并且与成人形式一样，嗜酸性筋膜炎、硬斑病和线状硬皮病之间的重叠也很模糊。青少年期硬皮病的病因发病机制尚不清楚，但几乎可以肯定是多因素的。其临床表达的异质性可能表明它不止是一种疾病。本综述试图记录硬皮病在儿童期的表现，并将其与病因、免疫和发病因素联系起来。
