Dow University of Health Sciences, Karachi.
4th Year MBBS Student, Dow International Medical College, Karachi, Pakistan.
J Pak Med Assoc. 2022 Feb;72(2):228-230. doi: 10.47391/JPMA.481.
To determine the effect of consuming water with high fluoride content on thyroid hormone status.
The comparative cross-sectional study was conducted at Sammu Rind village of district Tharparkar, Pakistan, where ground water was the only source of drinking and had fluoride content >6-8mg/dL, and another set of people from Gadap Town, Karachi, where ground water had fluoride level of 0.3mg/L. Thyroid profile, including serum thyroid stimulating hormone, free triiodothyronine and free thyroxine, were checked for both the exposed and the unexposed groups, and data was cross-tabulated with thyroid profile to check statistical significance. Data was analysed using SPSS 20.
Of the 242 subjects, 121(50%) each were in the exposed and the unexposed group. Among the exposed, 15(12.4%) people had hypothyroidism, 104(86%) had euthyroid and 2(1.6%) had hyperthyroid. Corresponding values in the unexposed group were 10(8%), 105(87%) and 6(5%). The difference was not statistically significant (p>0.05).
探讨摄氟水对甲状腺激素水平的影响。
本研究为对比性的横断面研究，在巴基斯坦信德省萨穆尔林德村进行，当地地下水是唯一的饮用水源，氟含量>6-8mg/dL；另一组人来自卡拉奇加达布镇，当地地下水氟含量为 0.3mg/L。对暴露组和非暴露组人群均进行甲状腺功能检查，包括血清促甲状腺激素、游离三碘甲状腺原氨酸和游离甲状腺素，将数据与甲状腺功能进行交叉制表，以检查统计学意义。使用 SPSS 20 进行数据分析。
在 242 名受试者中，暴露组和非暴露组各有 121 人（50%）。在暴露组中，有 15 人（12.4%）患有甲状腺功能减退症，104 人（86%）甲状腺功能正常，2 人（1.6%）患有甲状腺功能亢进症。非暴露组的相应数值分别为 10 人（8%）、105 人（87%）和 6 人（5%）。差异无统计学意义（p>0.05）。
