网格蛋白包被凹陷作为 Akt 信号通路的信号平台。
Clathrin coated pits as signaling platforms for Akt signaling.
机构信息
School of Biosciences, University of Sheffield, Sheffield, UK.
出版信息
J Cell Biol. 2022 Apr 4;221(4). doi: 10.1083/jcb.202203026. Epub 2022 Mar 23.
Abstract
Signaling by the activated epidermal growth factor receptor (EGFR) results in diverse cell fates. In this issue, Cabral-Dias et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.201808181) demonstrate how plasma membrane clathrin coated pits can act as a signaling platform for one branch of EGFR downstream signaling.
摘要
激活的表皮生长因子受体 (EGFR) 的信号转导导致多种细胞命运。在本期中，Cabral-Dias 等人（2022. J. Cell Biol. https://doi.org/10.1083/jcb.201808181）展示了质膜网格蛋白包被凹陷如何作为 EGFR 下游信号转导的一个分支的信号平台发挥作用。
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