Fütterer Klaus, Machesky Laura M
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Cell. 2007 May 18;129(4):655-7. doi: 10.1016/j.cell.2007.05.006.
Clathrin-mediated endocytosis is a key mechanism by which cells take up extracellular cargo. In this issue, Shimada et al. (2007) reveal the mode of action of the F-BAR domain, which deepens the initial membrane pit that forms during clathrin-mediated endocytosis.
网格蛋白介导的内吞作用是细胞摄取细胞外物质的关键机制。在本期杂志中,岛田等人(2007年)揭示了F-BAR结构域的作用方式,该结构域加深了网格蛋白介导的内吞作用过程中形成的初始膜凹陷。