Tver State Medical University.
G.N. Gabrichevskogo Moscow research institute for epidemiology and microbiology.
Klin Lab Diagn. 2022 Mar 25;67(3):163-169. doi: 10.51620/0869-2084-2022-67-3-163-169.
The work characterizes the intestinal microbiota of patients with ischemic stroke, including the spectrum, frequency and number of microorganisms, as well as the spectrum and amount of gas signaling molecules secreted by lactobacilli. It was found that in patients with ischemic stroke, the frequency of the main representatives of normal microflora, Bifidobacterium spp., Lactobacillus spp., Escherichia coli, decreased in 2-3 times, and the same time the prevalence of Clostridia spp., Bacillus spp., Peptostreptococcus spp., Klebsiella spp. increased in 2-3 times; yeast like fungi C. albicans was isolated in 25% of cases. Lactobacilli isolated from the intestinal microbiota of patients with ischemic stroke were represented by a wide variety of species: L. rhamnosus, L. fermentum, L. plantarum, L. brevis, L. pentosus, L. curvatus, L. salivarius. In most cases, they did not produce NO, they released CO 2 times less compared to healthy people. The most active NO producers - L. plantarum, CO - L. rhamnosus.
该工作描绘了缺血性脑卒中患者的肠道微生物群,包括微生物的种类、频率和数量,以及乳杆菌分泌的气体信号分子的种类和数量。研究发现,在缺血性脑卒中患者中,正常微生物群的主要代表双歧杆菌属、乳杆菌属、大肠杆菌的频率降低了 2-3 倍,而梭菌属、芽孢杆菌属、消化链球菌属、克雷伯菌属的流行率增加了 2-3 倍;25%的病例中分离出白色假丝酵母菌 C. albicans。从缺血性脑卒中患者肠道微生物群中分离出的乳杆菌具有广泛的物种多样性:鼠李糖乳杆菌、发酵乳杆菌、植物乳杆菌、短乳杆菌、戊糖片球菌、弯曲乳杆菌、唾液乳杆菌。在大多数情况下,它们不产生 NO,与健康人相比,它们释放的 CO2 少 2 倍。最活跃的 NO 产生菌为植物乳杆菌,CO 产生菌为鼠李糖乳杆菌。