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Challenges of studying 14-3-3 protein-protein interactions with full-length protein partners.

作者信息

Somsen Bente A, Ottmann Christian

机构信息

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.

出版信息

Biophys J. 2022 Apr 5;121(7):1115-1116. doi: 10.1016/j.bpj.2022.03.007. Epub 2022 Mar 9.

Abstract
摘要

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Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains.
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14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains.
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