Emergency Internal Medicine, LuHe Hospital of Capital Medical University, Beijing, China.
J BUON. 2021 Jul-Aug;26(4):1460-1465.
To detect differential expressions of HEIH and DKK3 in gastric cancer (GC) samples, and to elucidate their influences on clinical features and disease prognosis.
The expression levels of HEIH and DKK3 in GC tissues and adjacent normal ones (>5 cm) were detected by qRT-PCR. Correlation between HEIH and DKK3 levels in GC tissues was analyzed by Pearson's correlation analysis. Sensitivity and specificity of detecting HEIH and DKK3 levels in diagnosing GC were assessed by reactive oxygen species (ROC). 5-year survival in each patient was followed up. Risk factors of prognosis in GC patients were examined by Cox regression model.
HEIH was upregulated, and DKK3 was downregulated in GC tissues, displaying a negative correlation. Both HEIH and DKK3 were correlated to tumor diameter, lymph node metastasis and TNM staging. Combined detection of HEIH and DKK3 levels showed high specificity and sensitivity in the diagnosis of GC. Tumor diameter, lymph node metastasis, TNM staging, HEIH and DKK3 levels were independent risk factors for the prognosis of GC.
The upregulated HEIH and downregulated DKK3 in GC samples showed a negative correlation between each other. HEIH and DKK3 levels were closely linked to tumor diameter, lymph node metastasis and TNM staging in GC patients. These are promising biomarkers for predicting the prognosis of GC.
检测胃癌（GC）样本中 HEIH 和 DKK3 的差异表达，并阐明它们对临床特征和疾病预后的影响。
通过 qRT-PCR 检测 GC 组织和相邻正常组织（>5cm）中 HEIH 和 DKK3 的表达水平。通过 Pearson 相关分析分析 GC 组织中 HEIH 和 DKK3 水平之间的相关性。通过活性氧物质（ROC）评估检测 HEIH 和 DKK3 水平诊断 GC 的敏感性和特异性。对每位患者进行 5 年生存随访。通过 Cox 回归模型检查 GC 患者预后的危险因素。
HEIH 在 GC 组织中上调，DKK3 下调，呈负相关。HEIH 和 DKK3 均与肿瘤直径、淋巴结转移和 TNM 分期相关。联合检测 HEIH 和 DKK3 水平在 GC 诊断中具有较高的特异性和敏感性。肿瘤直径、淋巴结转移、TNM 分期、HEIH 和 DKK3 水平是 GC 预后的独立危险因素。
GC 样本中上调的 HEIH 和下调的 DKK3 之间呈负相关。HEIH 和 DKK3 水平与 GC 患者的肿瘤直径、淋巴结转移和 TNM 分期密切相关。这些是预测 GC 预后的有前途的生物标志物。
