Zhu Yongjian, Liu Mingjing, Fu Wanrong, Bo Yacong
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Clinical Medicine, Sanquan College of Xinxiang Medical University, Xinxiang, China.
Front Cardiovasc Med. 2022 Mar 7;9:813244. doi: 10.3389/fcvm.2022.813244. eCollection 2022.
Exposure to ambient pollutants and chemicals were found to be associated with increased risk of hypertension. However, the relationship between the increased aldehyde exposure and hypertension are still unclear. This study aimed to investigate the potential associations of serum aldehydes levels with prevalent hypertension.
A total of 1,733 U.S. adults with data on hypertension outcome and serum aldehydes measurement from the National Health and Nutrition Examination Survey 2013-2014 were included. The serum levels of aldehydes were measured an automated analytical method using solid phase microextraction gas chromatography and high-resolution mass spectrometry. Multivariate logistic regression models were adopted to assess the associations between six selected aldehydes exposure (benzaldehyde, butyraldehyde, heptanaldehyde, hexanaldehyde, isopentanaldehyde, and propanaldehyde) and prevalence of hypertension.
The mean age was 48.0 ± 16.7 years and an approximately equivalent of sex distribution was observed (female 49.9%). There seems to be a numerically higher level of hexanaldehyde in participants with hypertension when compared to participants without hypertension (2.6 ± 3.9 ng/mL vs. 2.3 ± 1.1 ng/mL). After adjusting for potential confounders, the odds ratio (OR) for hypertension was 2.15 [95% confidence interval (CI): 1.33-3.51] in participants from the highest quartile of serum hexanaldehyde concentration in comparison to those from the lowest quartile. Subgroup analyses and sensitivity analyses showed generally similar results.
In summary, current evidence suggested that increased serum hexanaldehyde level was positively associated with prevalent hypertension in U.S. adults.
研究发现，暴露于环境污染物和化学物质中会增加患高血压的风险。然而，醛暴露增加与高血压之间的关系仍不清楚。本研究旨在探讨血清醛水平与高血压患病率之间的潜在关联。
纳入了1733名来自2013 - 2014年美国国家健康与营养检查调查的成年人，这些人有高血压结局数据和血清醛测量数据。采用固相微萃取气相色谱和高分辨率质谱的自动化分析方法测量血清醛水平。采用多变量逻辑回归模型评估六种选定醛（苯甲醛、丁醛、庚醛、己醛、异戊醛和丙醛）暴露与高血压患病率之间的关联。
平均年龄为48.0±16.7岁，性别分布大致相等（女性占49.9%）。与无高血压的参与者相比，高血压参与者的己醛水平在数值上似乎更高（2.6±3.9 ng/mL对2.3±1.1 ng/mL）。在调整潜在混杂因素后，血清己醛浓度最高四分位数的参与者患高血压的比值比（OR）为2.15 [95%置信区间（CI）：1.33 - 3.51]，而最低四分位数的参与者。亚组分析和敏感性分析显示结果大致相似。
总之，目前的证据表明，血清己醛水平升高与美国成年人高血压患病率呈正相关。
