Huang Yi-Xia, He Guo-Xin, Zhang Wen-Jing, Li Bo-Wu, Weng Hai-Xu, Luo Wen-Chao
Intensive Care Unit, The Third Affiliated Hospital, Wenzhou Medical University, Ruian 330381, Zhejiang Province, China.
World J Clin Cases. 2022 Mar 6;10(7):2216-2221. doi: 10.12998/wjcc.v10.i7.2216.
Quetiapine, known as a non-classical antipsychotic drug, is frequently used for the treatment of mental diseases, such as schizophrenia, bipolar disorder, and major depressive disorder. Acute lung injury, a rarely reported side effect of quetiapine, is described in this case report.
Due to terminal delirium, a 66-year-old man took a large dose of quetiapine and then developed severe pulmonary disease. His symptoms were not resolved after routine treatment, such as antibiotics, diuretic, and supportive therapies. Quetiapine-related acute lung injury was therefore suspected and hormonal therapy was initiated. Subsequently, his symptoms were alleviated and the radiological results improved dramatically.
Our findings in the present report highlight a potential adverse effect of quetiapine, drug-related acute lung injury, which deserves awareness in clinical practice.
喹硫平作为一种非经典抗精神病药物，常用于治疗精神疾病，如精神分裂症、双相情感障碍和重度抑郁症。本病例报告描述了喹硫平一种罕见的副作用——急性肺损伤。
一名66岁男性因终末期谵妄服用了大剂量喹硫平，随后出现严重肺部疾病。经抗生素、利尿剂及支持性治疗等常规治疗后症状未缓解。因此怀疑为喹硫平相关的急性肺损伤，并开始激素治疗。随后，其症状缓解，影像学结果显著改善。
我们在本报告中的发现突出了喹硫平的一种潜在不良反应——药物相关的急性肺损伤，这在临床实践中值得引起重视。
