Laitinen O, Seppalä E, Nissilä M, Vapaatalo H
Clin Rheumatol. 1983 Dec;2(4):401-6. doi: 10.1007/BF02041562.
No significant differences were found in plasma concentrations and urinary excretion of prostaglandin E2 (PGE2), 6-keto-prostaglandin-F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TxB2), between rheumatoid arthritis patients and controls. However, urinary excretion of PGEe and 6-keto-PGF1 alpha tended to be greater and plasma levels of TxB2 lower in rheumatoid arthritis. Plasma concentrations and urinary excretion showed no marked circadian variation, although night or morning values were slightly lower. Plasma and urine prostaglandins do not correlate with clinical symptomatology in rheumatoid arthritis.
类风湿关节炎患者与对照组之间，前列腺素E2（PGE2）、6-酮-前列腺素F1α（6-酮-PGF1α）和血栓素B2（TxB2）的血浆浓度及尿排泄量未发现显著差异。然而，类风湿关节炎患者中PGE2和6-酮-PGF1α的尿排泄量有升高趋势，而TxB2的血浆水平则较低。尽管夜间或早晨的值略低，但血浆浓度和尿排泄量没有明显的昼夜变化。类风湿关节炎患者的血浆和尿液前列腺素与临床症状无相关性。
