Zheng Sulin, Qiu Min, Wu Jason H Y, Pan Xiong-Fei, Liu Xiong, Sun Lichang, Zhu Hailan, Wu Jiandi, Huang Yuli
Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.
The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW, Australia.
Ther Adv Chronic Dis. 2022 Mar 18;13:20406223221081616. doi: 10.1177/20406223221081616. eCollection 2022.
Adequate intake of long-chain (LC) omega-3 polyunsaturated fatty acids (-3 PUFAs) is considered important for cardiovascular health. However, the effects of LC -3 PUFAs on the risk of heart failure (HF) remain unclear. This systematic review and meta-analysis aimed to determine the role of LC -3 PUFAs in the incidence of HF.
Electronic databases were searched for studies up to 31 July 2021. Studies were included for the meta-analysis if they reported the adjusted associations between different dietary intakes or circulating concentrations of LC -3 PUFAs and the risk of HF. A random-effect model was used to calculate the pooled estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for higher LC -3 PUFA concentrations.
Thirteen studies were included in the meta-analysis. Eight studies comprising 316,698 individuals (11,244 incident HF cases), with a median follow-up of 10.7 years, showed that a higher dietary intake of LC -3 PUFAs was associated with a lower risk of HF (highest lowest quintile: HR = 0.84, 95% CI = 0.75-0.94). Six studies, comprising 17,163 participants (2520 HF cases) with a median follow-up of 9.7 years, showed that higher circulating LC -3 PUFA concentrations were associated with a lower risk of HF (highest lowest quintile: HR = 0.59, 95% CI = 0.39-0.91). Higher circulating docosahexaenoic acid concentrations were associated with a decreased risk of HF (top bottom quintile: HR = 0.44, 95% CI = 0.26-0.77). The associations between eicosapentaenoic acid (HR = 0.58, 95% CI = 0.26-1.25), docosahexaenoic acid (HR = 0.66, 95% CI = 0.24-1.82), and the risk of HF were not significant.
High LC -3 PUFA concentrations measured by dietary intake or circulating biomarkers are associated with a lower risk of developing HF.
充足摄入长链（LC）ω-3多不饱和脂肪酸（-3 PUFAs）被认为对心血管健康很重要。然而，LC -3 PUFAs对心力衰竭（HF）风险的影响仍不清楚。本系统评价和荟萃分析旨在确定LC -3 PUFAs在HF发病中的作用。
检索截至2021年7月31日的电子数据库中的研究。如果研究报告了不同饮食摄入量或循环浓度的LC -3 PUFAs与HF风险之间的校正关联，则纳入荟萃分析。采用随机效应模型计算较高LC -3 PUFA浓度的合并估计风险比（HRs）和95%置信区间（CIs）。
13项研究纳入荟萃分析。8项研究共316,698人（11,244例HF发病病例），中位随访10.7年，结果显示较高的LC -3 PUFAs饮食摄入量与较低的HF风险相关（最高 最低五分位数：HR = 0.84，95% CI = 0.75 - 0.94）。6项研究共17,163名参与者（2520例HF病例），中位随访9.7年，结果显示较高的循环LC -3 PUFA浓度与较低的HF风险相关（最高 最低五分位数：HR = 0.59，95% CI = 0.39 - 0.91）。较高的循环二十二碳六烯酸浓度与HF风险降低相关（最高 最低五分位数：HR = 0.44，95% CI = 0.26 - 0.77）。二十碳五烯酸（HR = 0.58，95% CI = 0.26 - 1.25）、二十二碳六烯酸（HR = 0.66，95% CI = 0.24 - 1.82）与HF风险之间的关联不显著。
通过饮食摄入量或循环生物标志物测量的高LC -3 PUFA浓度与较低的HF发病风险相关。
