Wang Yue, Jiang Liqing, Li Baoxuan, Zhao Yan
Department of Obstetrics and Gynaecology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Medical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Front Oncol. 2022 Mar 7;12:826703. doi: 10.3389/fonc.2022.826703. eCollection 2022.
Given the increasing number and survival rates of reproductive-age patients with chronic myeloid leukemia (CML), several studies aimed to elucidate optimum disease management in pregnancy. This study aimed to use bibliometric analysis to assess focus and reported insights, as well as future trends, in CML and pregnancy research.
We extracted all studies related to CML and pregnancy from the Web of Science database from 2001 to 2020. VOS Viewer, CiteSpace, Python, and R-bibliometrix were used for bibliometric analysis, revealing the leading research countries, institutions, and authors, as well as distribution of keywords (frequency greater than five).
A total of 196 records, published in 137 journals by 1,105 authors from 421 research institutes in 50 countries, were identified for analysis. The United States was the leader in the number of publications. Imperial College London and National Research Center for Hematology were the most influential institutions. In addition, Apperley J, Cortes J, Abruzzese E and Kantarjian H were the leading authors in the field. Keyword analysis identified four research hotspot clusters.
This study systematically analyzed the progress in CML and pregnancy research in the last 20 years. The present findings suggest that the management of planned and unplanned pregnancies in patients with CML will remain a research focus, as further evidence is required for the development of treatment guidelines.
鉴于慢性髓性白血病（CML）育龄患者数量及生存率不断增加，多项研究旨在阐明孕期的最佳疾病管理方法。本研究旨在运用文献计量分析评估CML与妊娠研究的重点、已报道的见解以及未来趋势。
我们从2001年至2020年的科学网数据库中提取了所有与CML和妊娠相关的研究。使用VOS Viewer、CiteSpace、Python和R-bibliometrix进行文献计量分析，揭示主要研究国家、机构和作者，以及关键词分布（频率大于5）。
共识别出196条记录，由来自50个国家421个研究机构的1105位作者发表在137种期刊上，用于分析。美国在出版物数量上领先。伦敦帝国学院和国家血液学研究中心是最具影响力的机构。此外，阿珀利·J、科尔特斯·J、阿布鲁泽塞·E和坎塔尔吉安·H是该领域的主要作者。关键词分析确定了四个研究热点集群。
本研究系统分析了过去20年CML与妊娠研究的进展。目前的研究结果表明，CML患者计划内和计划外妊娠的管理仍将是一个研究重点，因为制定治疗指南还需要更多证据。
