Department of Obstetrics and Gynaecology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Immunol. 2023 Jan 9;13:1036461. doi: 10.3389/fimmu.2022.1036461. eCollection 2022.
A growing evidence suggests that immune cells play a significant role in the pathogenesis of hypertensive disorders of pregnancy (HDP).Over the past 20 years, several studies have been conducted on the role of immune cells in hypertensive disorders of pregnancy. This study used bibliometric analysis to assess research hotspots and future trends in studies on immune cells in hypertensive disorders of pregnancy.
We extracted all relevant literature on immune cells and hypertensive disorders of pregnancy from the Web of Science core collection for the period of 2001 to 2021. We used VOS Viewer, CiteSpace, R-bibliometrix and Python for bibliometric analysis.
We identified 2,388 records published in 593 journals by 9,886 authors from 2,174 universities/institutions in 91 countries/regions. The number of publications tended to increase over time, with the highest number of publications in 2021, up to 205. The USA was the country with the most publications. UNIVERSITY OF MISSISSIPPI was the most influential institution. Lamarca B, Romero R, and Saito S were the most prolific authors. Finally, three research hotspot clusters were identified based on keywords, which reflected the role of immune cells in the development of hypertensive disorders of pregnancy, the current research status,and predicted hot spots for future research.
Our study systematically analyzed the role of immune cells in the pathogenesis of hypertensive disorders of pregnancy in the last 20 years. Our results indicated that immune cells, such as T cells, natural killer (NK) cells,and macrophages, and the cytokines released such as TNF-α, IFN-γ in the maternal circulation and at the maternal-fetal interface would influence the development of hypertensive disorders of pregnancy and we need further investigate the role of individual immune cells and translational studies to provide new therapeutic perspectives to mitigate adverse perinatal outcomes due to hypertensive disorders of pregnancy. In conclusion, bibliometric studies provide a general overview of immune cells in the study of hypertensive disorders of pregnancy.
越来越多的证据表明，免疫细胞在妊娠高血压疾病（HDP）的发病机制中起着重要作用。在过去的 20 年中，已经有几项关于免疫细胞在妊娠高血压疾病中的作用的研究。本研究使用文献计量学分析评估了免疫细胞与妊娠高血压疾病相关研究的热点和未来趋势。
我们从 Web of Science 核心合集提取了 2001 年至 2021 年期间与免疫细胞和妊娠高血压疾病相关的所有文献。我们使用 VOS Viewer、CiteSpace、R-bibliometrix 和 Python 进行文献计量分析。
我们从 91 个国家/地区的 2174 所大学/机构中确定了 9886 位作者在 593 种期刊上发表的 2388 篇记录。发表的文献数量随时间呈增加趋势，2021 年发表的文献数量最多，达到 205 篇。美国是发表文献最多的国家。密西西比大学是最具影响力的机构。Lamarca B、Romero R 和 Saito S 是最多产的作者。最后，根据关键词确定了三个研究热点群，反映了免疫细胞在妊娠高血压疾病发展中的作用、当前的研究现状，并预测了未来的研究热点。
本研究系统分析了过去 20 年免疫细胞在妊娠高血压疾病发病机制中的作用。我们的结果表明，母体循环和母胎界面中的免疫细胞（如 T 细胞、自然杀伤（NK）细胞和巨噬细胞）以及细胞因子（如 TNF-α、IFN-γ）会影响妊娠高血压疾病的发展，我们需要进一步研究个别免疫细胞的作用和转化研究，为减轻妊娠高血压疾病引起的不良围产期结局提供新的治疗视角。总之，文献计量学研究为妊娠高血压疾病中免疫细胞的研究提供了一个总体概述。
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