Kattapuram S V, Phillips W C, Mankin H J
Radiology. 1986 Nov;161(2):493-8. doi: 10.1148/radiology.161.2.3532194.
The authors retrospectively evaluated the clinical records and radiographs obtained from 41 patients who had giant cell tumor of bone and who were treated by local resection and allograft replacement. Postoperative complications developed in 41% of the patients. However, the eventual clinical outcome was considered to be satisfactory in 85% of all cases. There were no instances of tumor recurrence, and surprisingly, postoperative arthritis was not a major problem. The major complications encountered were infection and allograft fracture; bone infection accounted for most of the clinical failures. All infections were associated with the increasing soft-tissue swelling and bone resorption detected on radiographic studies. Other radiographic parameters that were associated with an increased rate of complications included osteopenia, increased periosteal reaction, and decreased bone formation at the host-donor junction site. The clinical outcome was distinctly less favorable in those cases in which the patient had had a pathologic fracture or a previous resection, or in whom the graft was implanted at the distal radius.
作者回顾性评估了41例骨巨细胞瘤患者的临床记录和X线片，这些患者均接受了局部切除和同种异体骨移植替代治疗。41%的患者出现了术后并发症。然而，最终85%的病例临床结果被认为是满意的。没有肿瘤复发的情况，而且令人惊讶的是，术后关节炎并不是一个主要问题。遇到的主要并发症是感染和同种异体骨骨折；骨感染是大多数临床治疗失败的原因。所有感染均与X线检查发现的软组织肿胀增加和骨吸收有关。与并发症发生率增加相关的其他X线参数包括骨质减少、骨膜反应增加以及宿主-供体交界部位骨形成减少。在患者曾发生病理性骨折或既往接受过切除术，或移植物植入桡骨远端的病例中，临床结果明显较差。
