Department of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University.
Tohoku J Exp Med. 2022 Jun 8;257(2):135-145. doi: 10.1620/tjem.2022.J008. Epub 2022 Mar 24.
Dysregulated expression of ubiquitin-specific protease 43 (USP43) has been recently discovered in malignancies. This study aimed to investigate the expression pattern of USP43 protein in lung squamous cell carcinoma (LUSC) and to explore its correlation with patients' clinicopathological characteristics as well as clinical outcomes. Expression of USP43 protein was determined by immunohistochemistry staining in a retrospective cohort containing 157 LUSC cases who underwent curative surgery in our hospital. Accordingly, USP43 protein was positively correlated with tumor size, depth of invasion, and lymph node metastasis. Patients with increased USP43 expression or positive lymph nodes exhibited a poorer overall survival. In addition, cellular assays elucidated that USP43 can promote LUSC growth and invasion. Taken together, our study demonstrated that USP43 may act as a proto-oncogene, which could be a promising biomarker and therapeutic target in the survival prediction and treatment of LUSC.
USP43 蛋白在肺鳞状细胞癌中的表达及其与临床病理特征和预后的关系
泛素特异性蛋白酶 43（USP43）的表达失调最近在恶性肿瘤中被发现。本研究旨在探讨 USP43 蛋白在肺鳞状细胞癌（LUSC）中的表达模式，并探讨其与患者临床病理特征和临床结局的相关性。通过对在我院接受根治性手术的 157 例 LUSC 患者的回顾性队列进行免疫组织化学染色，确定 USP43 蛋白的表达。USP43 蛋白的表达与肿瘤大小、浸润深度和淋巴结转移呈正相关。USP43 表达增加或淋巴结阳性的患者总生存较差。此外，细胞实验阐明 USP43 可以促进 LUSC 的生长和侵袭。综上所述，本研究表明 USP43 可能作为一种原癌基因，可作为 LUSC 患者生存预测和治疗的有前途的生物标志物和治疗靶点。
