Zhao Ziqi, Liu Meichen, Lin Zhikun, Zhu Mengru, Lv Linlin, Zhu Xinqing, Fan Rui, Al-Danakh Abdullah, He Hui, Tan Guang
Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
Aging (Albany NY). 2024 Apr 8;16(7):6613-6626. doi: 10.18632/aging.205731.
Ubiquitination of the proteins is crucial for governing protein degradation and regulating fundamental cellular processes. Deubiquitinases (DUBs) have emerged as significant regulators of multiple pathways associated with cancer and other diseases, owing to their capacity to remove ubiquitin from target substrates and modulate signaling. Consequently, they represent potential therapeutic targets for cancer and other life-threatening conditions. USP43 belongs to the DUBs family involved in cancer development and progression. This review aims to provide a comprehensive overview of the existing scientific evidence implicating USP43 in cancer development. Additionally, it will investigate potential small-molecule inhibitors that target DUBs that may have the capability to function as anti-cancer medicines.
蛋白质的泛素化对于控制蛋白质降解和调节基本细胞过程至关重要。去泛素化酶（DUBs）已成为与癌症和其他疾病相关的多种途径的重要调节因子，这是因为它们能够从靶底物上去除泛素并调节信号传导。因此，它们是癌症和其他危及生命疾病的潜在治疗靶点。USP43属于参与癌症发生和发展的去泛素化酶家族。本综述旨在全面概述现有科学证据，表明USP43与癌症发生有关。此外，还将研究靶向去泛素化酶的潜在小分子抑制剂，这些抑制剂可能具有作为抗癌药物的功能。
