Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites.
作者信息
Liu Yang, Zhou Jizeng, Lan Ting, Zhou Xiaoqing, Yang Yang, Li Chuan, Zhang Quanjun, Chen Min, Wei Shu, Zheng Shuwen, Cheng Lingyin, Zheng Yuling, Lai Liangxue, Zou Qingjian
机构信息
CAS Key Laboratory of Regenerative Biology, Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Joint Research Laboratory on Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.
出版信息
Cell Discov. 2022 Mar 23;8(1):28. doi: 10.1038/s41421-022-00384-4.
Abstract
摘要
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