Uddman R, Edvinsson L, Ekblad E, Håkanson R, Sundler F
Regul Pept. 1986 Aug;15(1):1-23. doi: 10.1016/0167-0115(86)90071-6.
The distribution of perivascular nerve fibers displaying calcitonin gene-related peptide (CGRP) immunoreactivity and the effect of CGRP on vascular smooth muscle were studied in the guinea-pig. Perivascular CGRP fibers were seen in all vascular beds. Generally, they were more numerous around arteries than veins. Small arteries in the respiratory tract, gastrointestinal tract and genitourinary tract had numerous CGRP fibers. The gastroepiploic artery in particular received a rich supply of such fibers. Coronary blood vessels had a moderate supply of CGRP fibers. In the heart, a moderate number of CGRP fibers was seen running close to myocardial fibers. The atria had a richer supply than the ventricles. Numerous CGRP immunoreactive nerve cell bodies and nerve fibers were seen in sensory (trigeminal, jugular and spinal dorsal root) ganglia. Sequential or double immunostaining with antibodies against substance P and CGRP suggested co-existence of the two peptides in nerve cell bodies in the ganglia and in perivascular fibers. In agreement with previous findings CGRP turned out to be a strong vasodilator in vitro as tested on several blood vessels (e.g. basilar, gastroepiploic and mesenteric arteries). Conceivably, perivascular CGRP/SP fibers have a dual role as regulator of local blood flow and as carrier of sensory information.
在豚鼠中研究了显示降钙素基因相关肽（CGRP）免疫反应性的血管周围神经纤维的分布以及CGRP对血管平滑肌的作用。在所有血管床中均可见血管周围CGRP纤维。一般来说，动脉周围的此类纤维比静脉周围更多。呼吸道、胃肠道和泌尿生殖道的小动脉有大量CGRP纤维。特别是胃网膜动脉接受了丰富的此类纤维供应。冠状血管有中等数量的CGRP纤维供应。在心脏中，可见中等数量的CGRP纤维靠近心肌纤维走行。心房的纤维供应比心室丰富。在感觉（三叉神经、颈静脉和脊髓背根）神经节中可见大量CGRP免疫反应性神经细胞体和神经纤维。用抗P物质和CGRP的抗体进行顺序或双重免疫染色表明，这两种肽在神经节的神经细胞体和血管周围纤维中共存。与先前的研究结果一致，在对几条血管（如基底动脉、胃网膜动脉和肠系膜动脉）进行的体外测试中，CGRP被证明是一种强效血管扩张剂。可以想象，血管周围的CGRP/SP纤维具有作为局部血流调节剂和感觉信息载体的双重作用。
